Publication: Circulating cardiac troponin T in skeletal muscle disease: A reflection of re-expression phenomenon?
Issued Date
2018-09-01
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ISSN
22288082
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2-s2.0-85057539107
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Mahidol University
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SCOPUS
Bibliographic Citation
Siriraj Medical Journal. Vol.70, No.5 (2018), 459-465
Suggested Citation
Kosit Sribhen, Pusadee Luenee Circulating cardiac troponin T in skeletal muscle disease: A reflection of re-expression phenomenon?. Siriraj Medical Journal. Vol.70, No.5 (2018), 459-465. doi:10.14456/smj.2018.73 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/46360
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Title
Circulating cardiac troponin T in skeletal muscle disease: A reflection of re-expression phenomenon?
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Abstract
© 2018 Siriraj Medical Journal. Determinations of cardiac troponin T (cTnT) and cardiac troponin I (cTnI) have replaced creatine kinase myocardial band (CK-MB) measurements as the "gold standard" biochemical methods for the detection of myocardial injury and infarction. Due to their high myocardial tissue specificity, it can can be assumed with a high probability that the troponins detected in the circulation are of cardiac origin. However, there have been several reports in recent years which showed increased serum concentrations of cTnT, but not of cTnI, in patients with skeletal muscle disorders, in whom no clinical evidence of myocardial cell damage were observed. Since cTnT isoform, in contrast to cTnI isoform, has been reported to be expressed in fetal skeletal muscle, there is the possibility that this fetal cTnT isoform is re-expressed in diseased and regenerating adult skeletal muscle. Therefore, the reported high myocardial tissue specificity of cTnT is to be questioned, and elevated cTnT concentrations found in patients with destructive skeletal muscle disease should be cautiously interpreted as biochemical evidence of myocardial cell injury. This present review describes the physiological and pathophysiological aspects of cTnT and cTnI in health and disease, with special emphasis on the tissue expression of their isoforms in the fetal and adult hearts as well as in the fetal and adult skeletal muscles. Previous and recent data, obtained from international databases (PubMed, Scopus, Google Scholar), with reports on cardiac biomarkers in patients with acute and chronic skeletal muscle disorders are summarized and the clinical implications of these findings are also addressed and discussed.