Publication: Combination therapy of prostacyclin for pulmonary hypertension in congenital heart disease
Issued Date
2005-08-01
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ISSN
01252208
01252208
01252208
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2-s2.0-31744446401
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Mahidol University
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SCOPUS
Bibliographic Citation
Journal of the Medical Association of Thailand. Vol.88, No.SUPPL. 8 (2005)
Suggested Citation
Kritvikrom Durongpisitkul, Decho Jakrapanichakul, Duangmanee Laohaprasitiporn, Jarupim Soongswang, Prakul Chanthong, Apichart Nana Combination therapy of prostacyclin for pulmonary hypertension in congenital heart disease. Journal of the Medical Association of Thailand. Vol.88, No.SUPPL. 8 (2005). Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/16892
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Title
Combination therapy of prostacyclin for pulmonary hypertension in congenital heart disease
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Abstract
Background: Pulmonary arterial hypertension (PAH) is a recognized complication of congenital heart disease. Despite differences in etiology and pathophysiology, successful therapy for idiopathic PAH may benefit in patients with congenital heart disease. We theorized that combination of oral and aerosolization prostacyclin will benefit this group of patients in long term. Material and Method: The study design was single group and open label study with intention to treat for patients with congenital heart disease with pulmonary artery (PA pressure) more than 50% of systemic pressure. All patients were given a combination of orally given beraprost sodium and inhalation of iloprostfor 12 months. Data were collected prospectively consisting of functional class, O2 saturation, 6-minute walk test and right ventricular systolic pressure (RVSP). Results: There were 23 patients with an average right ventricular systolic pressure (± SD) of 94.8 ± 14.5 mmHg and with average age of 27.8 ± 14.9 years (2.5 to 50 years). The average oxygen saturation was 87.9 ± 7 %. There were 12 patients with post surgical repair or cardiac catheterization interventional procedure and 11 with and Eisenmenger's syndrome. There were significant improvement of 6-minute-walk test from an average of 268 ± 70 meters to 308 ± 57 meters at the end of 12 months. The functional class of patients was also improving. However, there were no significant different in oxygen saturation. Conclusion: Combination therapy of oral and inhalation of aerosolized vasodilators is a fascinating concept in the therapy of pulmonary hypertension. Treated patients showed an improvement in exercise capacity and right ventricular systolic pressure without a worsening in oxygen saturation.