Publication: E8002 inhibits peripheral nerve adhesion by enhancing fibrinolysis of l-ascorbic acid in a rat sciatic nerve model
Issued Date
2020-06-01
Resource Type
ISSN
14220067
16616596
16616596
Other identifier(s)
2-s2.0-85085947496
Rights
Mahidol University
Rights Holder(s)
SCOPUS
Bibliographic Citation
International Journal of Molecular Sciences. Vol.21, No.11 (2020)
Suggested Citation
Kiyoshi Kikuchi, Kentaro Setoyama, Seiya Takada, Shotaro Otsuka, Kazuki Nakanishi, Kosuke Norimatsu, Akira Tani, Harutoshi Sakakima, Ko Ichi Kawahara, Kazuya Hosokawa, Ryoji Kiyama, Megumi Sumizono, Salunya Tancharoen, Ikuro Maruyama, Gohsuke Hattori, Motohiro Morioka, Eiichiro Tanaka, Hisaaki Uchikado E8002 inhibits peripheral nerve adhesion by enhancing fibrinolysis of l-ascorbic acid in a rat sciatic nerve model. International Journal of Molecular Sciences. Vol.21, No.11 (2020). doi:10.3390/ijms21113972 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/57728
Research Projects
Organizational Units
Authors
Journal Issue
Thesis
Title
E8002 inhibits peripheral nerve adhesion by enhancing fibrinolysis of l-ascorbic acid in a rat sciatic nerve model
Other Contributor(s)
Kagoshima University Graduate School of Medical and Dental Sciences
Kyushu University of Nursing and Social Welfare
Osaka Institute of Technology
Kagoshima University
Kagoshima University Faculty of Medicine
Mahidol University
Kurume University School of Medicine
Uchikado Neuro-Spine Clinic
Fujimori Kogyo Co., Ltd.
Kyushu University of Nursing and Social Welfare
Osaka Institute of Technology
Kagoshima University
Kagoshima University Faculty of Medicine
Mahidol University
Kurume University School of Medicine
Uchikado Neuro-Spine Clinic
Fujimori Kogyo Co., Ltd.
Abstract
© 2020 by the authors. Perineural adhesions leading to neuropathy are one of the most undesirable consequences of peripheral nerve surgery. However, there are currently no widely used compounds with anti-adhesive effects in the field of peripheral nerve surgery. E8002 is a novel, anti-adhesive, multi-layer membrane that contains L-ascorbic acid (AA). Here, we investigated the effect and mechanism of E8002 in a rat sciatic nerve adhesion model. A total of 21 rats were used. Six weeks after surgery, macroscopic adhesion scores were significantly lower in the E8002 group (adhesion procedure followed by nerve wrapping with E8002) compared to the E8002 AA(−) group (adhesion procedure followed by nerve wrapping with the E8002 membrane excluding AA) and adhesion group (adhesion procedure but no treatment). Correspondingly, a microscopic examination revealed prominent scar tissue in the E8002 AA(−) and adhesion groups. Furthermore, an in vitro study using human blood samples showed that AA enhanced tissue-type, plasminogen activator-mediated fibrinolysis. Altogether, these results suggest that E8002 may exert an anti-adhesive action via AA and the regulation of fibrinolysis.