Publication: In vitro sensitivity of Plasmodium falciparum and clinical response to lumefantrine (benflumetol) and artemether
Issued Date
2000-05-10
Resource Type
ISSN
03065251
Other identifier(s)
2-s2.0-0034106867
Rights
Mahidol University
Rights Holder(s)
SCOPUS
Bibliographic Citation
British Journal of Clinical Pharmacology. Vol.49, No.5 (2000), 437-444
Suggested Citation
Peerapan Tanariya, Pongsri Tippawangkoso, Juntra Karbwang, Kesara Na-Bangchang, Walther H. Wernsdorfer In vitro sensitivity of Plasmodium falciparum and clinical response to lumefantrine (benflumetol) and artemether. British Journal of Clinical Pharmacology. Vol.49, No.5 (2000), 437-444. doi:10.1046/j.1365-2125.2000.00176.x Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/26244
Research Projects
Organizational Units
Authors
Journal Issue
Thesis
Title
In vitro sensitivity of Plasmodium falciparum and clinical response to lumefantrine (benflumetol) and artemether
Other Contributor(s)
Abstract
Aims. To assess the sensitivity of 103 Plasmodium falciparum isolates to a combination of lumefantrine (benflumetol) and artemether (CGP 56697), with the objective of determining a correlation between in vitro drug sensitivity and therapeutic outcome. Methods. Patients suffered from uncomplicated falciparum malaria and came from areas of Thailand affected by multidrug resistance. CGP 56697 was given in the form of tablets containing 20 mg artemether and 120 mg lumefantrine. The standard dose regimen, 4 doses of 4 tablets over 48 h, was compared with two lower dose regimens (4 x 2 tablets and 3 x 4 tablets). Results. The parasites showed high resistance to chloroquine, fairly advanced resistance to mefloquine and compromised sensitivity to quinine. Sensitivity to artemisinin and lumefantrine prior to treatment was similar in all treatment groups. The 4 x 4 tablet regimen was more effective than the other regimens in coping with infections with relatively low sensitivity to artemisinin and/or lumefantrine. The EC 90 for artemisinin is an important determinant of treatment success. Parasite density at the start of treatment was identified as another critical predictor of treatment outcome. Conclusions. The results indicate that parasite exposure to the drugs may have been inadequate and/or too short in the cases of treatment failure, particularly marked in the lower dose regimens. This could probably be remedied by expanding the dose regimen in areas affected by multidrug resistance and in the case of relatively high parasitaemia.