Publication: Cell-type specific variation in the induction of ER stress and downstream events in chikungunya virus infection
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Issued Date
2016-12-01
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ISSN
10961208
08824010
08824010
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2-s2.0-84996504036
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Mahidol University
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SCOPUS
Bibliographic Citation
Microbial Pathogenesis. Vol.101, (2016), 104-118
Suggested Citation
Sarawut Khongwichit, Nitwara Wikan, Bizunesh Abere, Chutima Thepparit, Atichat Kuadkitkan, Sukathida Ubol, Duncan R. Smith Cell-type specific variation in the induction of ER stress and downstream events in chikungunya virus infection. Microbial Pathogenesis. Vol.101, (2016), 104-118. doi:10.1016/j.micpath.2016.11.009 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/40729
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Title
Cell-type specific variation in the induction of ER stress and downstream events in chikungunya virus infection
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Abstract
© 2016 Elsevier Ltd Over the last decade infections with the mosquito transmitted chikungunya virus (CHIKV) have become a major worldwide concern, and considerable efforts have been made in understanding the interaction of this virus with the host cell machinery. Studies have documented the induction of the unfolded protein response (UPR), as well as the induction of apoptosis and autophagy in response to CHIKV infection. This study comparatively analysed these three processes in two cell lines, Hela and HepG2. Infection of Hela cells was characterized by activation of the PERK/eIF2α branch of the UPR, the induction of autophagy and early apoptosis, while infection of HepG2 cells was characterized by activation of the IRE/XBP1 branch of the UPR, limited or no activation of autophagy and comparatively later apoptosis. These results show that the specific cell context is an important mediator of the host cell response to CHIKV infection.