Publication:
Protective effect of melatonin on methamphetamine-induced apoptosis in glioma cell line

dc.contributor.authorPichaya Jumnongprakhonen_US
dc.contributor.authorPiyarat Govitrapongen_US
dc.contributor.authorChainarong Tocharusen_US
dc.contributor.authorWanida Tungkumen_US
dc.contributor.authorJiraporn Tocharusen_US
dc.contributor.otherChiang Mai Universityen_US
dc.contributor.otherMahidol Universityen_US
dc.contributor.otherNaresuan Universityen_US
dc.date.accessioned2018-11-09T03:07:57Z
dc.date.available2018-11-09T03:07:57Z
dc.date.issued2014-01-01en_US
dc.description.abstractMethamphetamine (METH) is a highly addictive drug causing neurodegenerative diseases. METH has been known to be neurotoxic by inducing oxidative stress, free radical, and pro-inflammatory cytokines. Previous studies have shown that METH could induce neuron and glial cell death, especially inducing glial cell-mediated neurotoxicity that plays a critical role in stress-induced central nervous system damage. Therefore, the aim of the present study is to explore the mechanisms of METH-induced cell death in the glial cell. METH-induced glial cells death is mediated via mitochondrial damage pathway. METH activates the upregulation of the Bax, cytochrome c, cleavage caspase 9 and 3 proteins, and downregulation of Bcl-XLprotein in cascade. Pretreatment with melatonin, a neurohormone secreted by the pineal gland, effectively reduced glial cell death. Moreover, melatonin increased the Bcl-XL/Bax ratio but reduced the level of cytochrome c, cleavage caspase 9 and 3 proteins. Therefore, these results demonstrated that melatonin could reduce the cytotoxic effect of METH by decreasing the mitochondrial death pathway activation in glial cells. This outcome suggests that melatonin might be beneficial as the neuroprotection in neurodegenerative diseases caused by METH or other pathogens. © 2013 Springer Science+Business Media.en_US
dc.identifier.citationNeurotoxicity Research. Vol.25, No.3 (2014), 286-294en_US
dc.identifier.doi10.1007/s12640-013-9419-yen_US
dc.identifier.issn14763524en_US
dc.identifier.issn10298428en_US
dc.identifier.other2-s2.0-84896030663en_US
dc.identifier.urihttps://repository.li.mahidol.ac.th/handle/20.500.14594/34889
dc.rightsMahidol Universityen_US
dc.rights.holderSCOPUSen_US
dc.source.urihttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84896030663&origin=inwarden_US
dc.subjectNeuroscienceen_US
dc.subjectPharmacology, Toxicology and Pharmaceuticsen_US
dc.titleProtective effect of melatonin on methamphetamine-induced apoptosis in glioma cell lineen_US
dc.typeArticleen_US
dspace.entity.typePublication
mu.datasource.scopushttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84896030663&origin=inwarden_US

Files

Collections