Publication:
R2d2 Drives Selfish Sweeps in the House Mouse

Issued Date

2016-06-02

Resource Type

Article

ISSN

15371719
07374038

DOI

10.1093/molbev/msw036

Other identifier(s)

2-s2.0-84973402664

Rights

Mahidol University

Rights Holder(s)

SCOPUS

Bibliographic Citation

Molecular Biology and Evolution. Vol.33, No.6 (2016), 1381-1395

Suggested Citation

John P. Didion, Andrew P. Morgan, Liran Yadgary, Timothy A. Bell, Rachel C. McMullan, Lydia Ortiz De Solorzano, Janice Britton-Davidian, Carol J. Bult, Karl J. Campbell, Riccardo Castiglia, Yung Hao Ching, Amanda J. Chunco, James J. Crowley, Elissa J. Chesler, Daniel W. Förster, John E. French, Sofia I. Gabriel, Daniel M. Gatti, Theodore Garland, Eva B. Giagia-Athanasopoulou, Mabel D. Giménez, Sofia A. Grize, Islam Gündüz, Andrew Holmes, Heidi C. Hauffe, Jeremy S. Herman, James M. Holt, Kunjie Hua, Wesley J. Jolley, Anna K. Lindholm, María J. López-Fuster, George Mitsainas, Maria Da Luz Mathias, Leonard McMillan, Maria Da Graça Morgado Ramalhinho, Barbara Rehermann, Stephan P. Rosshart, Jeremy B. Searle, Meng Shin Shiao, Emanuela Solano, Karen L. Svenson, Patricia Thomas-Laemont, David W. Threadgill, Jacint Ventura, George M. Weinstock, Daniel Pomp, Gary A. Churchill, Fernando Pardo Manuel De Villena R2d2 Drives Selfish Sweeps in the House Mouse. Molecular Biology and Evolution. Vol.33, No.6 (2016), 1381-1395. doi:10.1093/molbev/msw036 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/43365

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Title

R2d2 Drives Selfish Sweeps in the House Mouse

Author(s)

John P. Didion
 Andrew P. Morgan
 Liran Yadgary
 Timothy A. Bell
 Rachel C. McMullan
 Lydia Ortiz De Solorzano
 Janice Britton-Davidian
 Carol J. Bult
 Karl J. Campbell
 Riccardo Castiglia
 Yung Hao Ching
 Amanda J. Chunco
 James J. Crowley
 Elissa J. Chesler
 Daniel W. Förster
 John E. French
 Sofia I. Gabriel
 Daniel M. Gatti
 Theodore Garland
 Eva B. Giagia-Athanasopoulou
 Mabel D. Giménez
 Sofia A. Grize
 Islam Gündüz
 Andrew Holmes
 Heidi C. Hauffe
 Jeremy S. Herman
 James M. Holt
 Kunjie Hua
 Wesley J. Jolley
 Anna K. Lindholm
 María J. López-Fuster
 George Mitsainas
 Maria Da Luz Mathias
 Leonard McMillan
 Maria Da Graça Morgado Ramalhinho
 Barbara Rehermann
 Stephan P. Rosshart
 Jeremy B. Searle
 Meng Shin Shiao
 Emanuela Solano
 Karen L. Svenson
 Patricia Thomas-Laemont
 David W. Threadgill
 Jacint Ventura
 George M. Weinstock
 Daniel Pomp
 Gary A. Churchill
 Fernando Pardo Manuel De Villena

Other Contributor(s)

The University of North Carolina at Chapel Hill
 Université de Montpellier
 Jackson Laboratory
 Island Conservation
 University of Queensland
 Università degli Studi di Roma La Sapienza
 Tzu Chi University
 Elon University
 Leibniz-Institut fur Zoo- und Wildtierforschung
 National Institute of Environmental Health Sciences
 Faculdade de Ciências, Universidade de Lisboa
 University of California, Riverside
 Panepistimion Patron
 Instituto de Biologia Subtropical
 University of Zurich
 Ondokuz Mayis University Faculty of Science and Arts
 National Institute on Alcohol Abuse and Alcoholism
 Istituto Agrario San Michele all'Adige
 National Museums of Scotland
 Island Conservation
 Universitat de Barcelona
 National Institute of Diabetes and Digestive and Kidney Diseases
 Cornell University
 Mahidol University
 Texas A and M University
 Universitat Autònoma de Barcelona
 Jackson Laboratory for Genomic Medicine

Abstract

© 2016 The Author 2016. Published by Oxford University Press on behalf of the Society for Molecular Biology and Evolution. A selective sweep is the result of strong positive selection driving newly occurring or standing genetic variants to fixation, and can dramatically alter the pattern and distribution of allelic diversity in a population. Population-level sequencing data have enabled discoveries of selective sweeps associated with genes involved in recent adaptations in many species. In contrast, much debate but little evidence addresses whether "selfish" genes are capable of fixation - thereby leaving signatures identical to classical selective sweeps - despite being neutral or deleterious to organismal fitness. We previously described R2d2, a large copy-number variant that causes nonrandom segregation of mouse Chromosome 2 in females due to meiotic drive. Here we show population-genetic data consistent with a selfish sweep driven by alleles of R2d2 with high copy number (R2d2HC) in natural populations. We replicate this finding in multiple closed breeding populations from six outbred backgrounds segregating for R2d2 alleles. We find that R2d2HC rapidly increases in frequency, and in most cases becomes fixed in significantly fewer generations than can be explained by genetic drift. R2d2HC is also associated with significantly reduced litter sizes in heterozygous mothers, making it a true selfish allele. Our data provide direct evidence of populations actively undergoing selfish sweeps, and demonstrate that meiotic drive can rapidly alter the genomic landscape in favor of mutations with neutral or even negative effects on overall Darwinian fitness. Further study will reveal the incidence of selfish sweeps, and will elucidate the relative contributions of selfish genes, adaptation and genetic drift to evolution.

Keyword(s)

Agricultural and Biological Sciences
 Biochemistry, Genetics and Molecular Biology

Availability

URI

https://repository.li.mahidol.ac.th/handle/20.500.14594/43365

Collections

Scopus 2016-2017