Publication:
Assessment of therapeutic responses to gametocytocidal drugs in Plasmodium falciparum malaria

Issued Date

2014-12-09

Resource Type

Review

ISSN

14752875

DOI

10.1186/1475-2875-13-483

Other identifier(s)

2-s2.0-84926450796

Rights

Mahidol University

Rights Holder(s)

SCOPUS

Bibliographic Citation

Malaria Journal. Vol.13, No.1 (2014)

Suggested Citation

Nicholas J. White, Elizabeth A. Ashley, Judith Recht, Michael J. Delves, Andrea Ruecker, Frank M. Smithuis, Alice C. Eziefula, Teun Bousema, Chris Drakeley, Kesinee Chotivanich, Mallika Imwong, Sasithon Pukrittayakamee, Jetsumon Prachumsri, Cindy Chu, Chiara Andolina, Germana Bancone, Tran T. Hien, Mayfong Mayxay, Walter R.J. Taylor, Lorenz Von Seidlein, Ric N. Price, Karen I. Barnes, Abdoulaye Djimdé, Feiko Ter Kuile, Roly Gosling, Ingrid Chen, Mehul J. Dhorda, Kasia Stepniewska, Philippe Guérin, Charles J. Woodrow, Arjen M. Dondorp, Nicholas P.J. Day, Francois H. Nosten Assessment of therapeutic responses to gametocytocidal drugs in Plasmodium falciparum malaria. Malaria Journal. Vol.13, No.1 (2014). doi:10.1186/1475-2875-13-483 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/33942

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Title

Assessment of therapeutic responses to gametocytocidal drugs in Plasmodium falciparum malaria

Author(s)

Nicholas J. White
 Elizabeth A. Ashley
 Judith Recht
 Michael J. Delves
 Andrea Ruecker
 Frank M. Smithuis
 Alice C. Eziefula
 Teun Bousema
 Chris Drakeley
 Kesinee Chotivanich
 Mallika Imwong
 Sasithon Pukrittayakamee
 Jetsumon Prachumsri
 Cindy Chu
 Chiara Andolina
 Germana Bancone
 Tran T. Hien
 Mayfong Mayxay
 Walter R.J. Taylor
 Lorenz Von Seidlein
 Ric N. Price
 Karen I. Barnes
 Abdoulaye Djimdé
 Feiko Ter Kuile
 Roly Gosling
 Ingrid Chen
 Mehul J. Dhorda
 Kasia Stepniewska
 Philippe Guérin
 Charles J. Woodrow
 Arjen M. Dondorp
 Nicholas P.J. Day
 Francois H. Nosten

Other Contributor(s)

Mahidol University
 Nuffield Department of Clinical Medicine
 Imperial College London
 Myanmar Oxford Clinical Research Unit
 London School of Hygiene & Tropical Medicine
 UCL
 Mahosot Hospital
 Menzies School of Health Research
 University of Cape Town
 University of Bamako Faculty of Medicine, Pharmacy and Odonto-Stomatology
 Liverpool School of Tropical Medicine
 UCSF Global Health Sciences
 Churchill Hospital

Abstract

© 2014 White et al. Indirect clinical measures assessing anti-malarial drug transmission-blocking activity in falciparum malaria include measurement of the duration of gametocytaemia, the rate of gametocyte clearance or the area under the gametocytaemia-time curve (AUC). These may provide useful comparative information, but they underestimate dose-response relationships for transmission-blocking activity. Following 8-aminoquinoline administration P. falciparum gametocytes are sterilized within hours, whereas clearance from blood takes days. Gametocytaemia AUC and clearance times are determined predominantly by the more numerous female gametocytes, which are generally less drug sensitive than the minority male gametocytes, whereas transmission-blocking activity and thus infectivity is determined by the more sensitive male forms. In choosing doses of transmission-blocking drugs there is no substitute yet for mosquito-feeding studies.

Keyword(s)

Immunology and Microbiology
 Medicine

Availability

URI

https://repository.li.mahidol.ac.th/handle/20.500.14594/33942

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