Publication: False-positive serum and bronchoalveolar lavage Aspergillus galactomannan assays caused by different antibiotics
Issued Date
2010-01-01
Resource Type
ISSN
16511980
00365548
00365548
Other identifier(s)
2-s2.0-77953241924
Rights
Mahidol University
Rights Holder(s)
SCOPUS
Bibliographic Citation
Scandinavian Journal of Infectious Diseases. Vol.42, No.6-7 (2010), 461-468
Suggested Citation
Viboon Boonsarngsuk, Anuchit Niyompattama, Chalermporn Teosirimongkol, Kanchana Sriwanichrak False-positive serum and bronchoalveolar lavage Aspergillus galactomannan assays caused by different antibiotics. Scandinavian Journal of Infectious Diseases. Vol.42, No.6-7 (2010), 461-468. doi:10.3109/00365541003602064 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/29286
Research Projects
Organizational Units
Authors
Journal Issue
Thesis
Title
False-positive serum and bronchoalveolar lavage Aspergillus galactomannan assays caused by different antibiotics
Other Contributor(s)
Abstract
Our objective was to identify false-positive serum and bronchoalveolar lavage (BAL) fluid galactomannan (GM) tests caused by various antibiotics commonly used in general practice. Serum and BAL samples from patients who did not have the diagnostic criteria of invasive aspergillosis and received different antibiotics were prospectively analyzed for GM. Serum and BAL samples were also collected from patients who did not receive antibiotics. At the cut-off index of ≥0.5, false-positive serum results were found in patients who received amoxicillinclavulanate, piperacillintazobactam, cefepime, and cefoperazonesulbactam (26.7%, 58.3%, 14.3%, and 66.7%, respectively). Fungal colonization in BAL samples had a higher BAL GM than those without fungal colonization. In 71 patients who had a negative BAL culture for fungi, at the cut-off value of ≥1.0, false-positive BAL fluid results were found in patients who received amoxicillinclavulanate (27.3%), piperacillintazobactam (50%), cefepime (16.7%), carbapenem (45.5%), and ceftriaxone (45.5%). False-positive serum and BAL GM assays were also detected in patients who did not receive any antibiotics. In summary, this study demonstrates the false-positive GM levels in serum and BAL caused by β-lactam antibiotics that are commonly used in general practice. Physicians should be aware of this possible interference. © 2010 Informa UK Ltd.