Publication: Blood coagulation and asthma exacerbation in children
Issued Date
2016-08-01
Resource Type
ISSN
14230097
10182438
10182438
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2-s2.0-84980401204
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Mahidol University
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SCOPUS
Bibliographic Citation
International Archives of Allergy and Immunology. Vol.170, No.2 (2016), 75-83
Suggested Citation
Wiparat Manuyakorn, Dara Mairiang, Nongnuch Sirachainan, Praguywan Kadegasem, Wasu Kamchaisatian, Suwat Benjaponpitak, Ampaiwan Chuansumrit Blood coagulation and asthma exacerbation in children. International Archives of Allergy and Immunology. Vol.170, No.2 (2016), 75-83. doi:10.1159/000446775 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/40757
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Title
Blood coagulation and asthma exacerbation in children
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Abstract
© 2016 S. Karger AG, Basel. Background: Recent studies have demonstrated the activation of coagulation pathways in asthmatic airways. This study aimed to determine systemic blood coagulation during asthma exacerbation compared with the stable state in children. Methods: Pediatric patients (aged between 5 and 15 years) suffering from asthma exacerbation were enrolled. von Willebrand factor (vWF), plasminogen activator inhibitor type-1 (PAI-1), protein C, D-dimer, prothrombin fragment 1 + 2 (F1 + 2), thrombin-antithrombin complex (TAT), and C-reactive protein (CRP) levels were measured during asthma exacerbation and stable state. Results: A total of 22 patients were enrolled. The median vWF, PAI-1, and CRP during asthma exacerbation were significantly higher than those of the stable state: 147.5% (interquartile range, IQR: 111.05-196.57) versus 94% (IQR: 69.72-109.62, p < 0.001), 41.9 ng/ml (IQR: 21.91-48.61) versus 26.17 ng/ml (IQR: 15.89-34.44, p < 0.03), and 4.46 mg/l (IQR: 2.15-16.23) versus 0.87 mg/l (IQR: 0.20-3.89, p < 0.015), respectively. However, the median protein C during asthma exacerbation was significantly lower than that of the stable state: 99.5% (IQR: 86.75-117) versus 113% (IQR: 94-115.25), p = 0.01. No significant difference was found between the levels of D-dimer, F1 + 2, and TAT during asthma exacerbation and stable state. Ultimately, D-dimer was positively correlated with asthma exacerbation score (R = 0.466, p = 0.027). A significant correlation was observed between vWF and CRP (R = 0.527, p = 0.012). Conclusion: Evidence was found of increased endothelial activation and increased PAI-1 during asthma exacerbation. This may emphasize the potential role of blood coagulation in asthma exacerbation.