Publication: In vivo transmission blocking activities of artesunate on the avian malaria parasite Plasmodium gallinaceum
Issued Date
2013-10-08
Resource Type
ISSN
18732550
03044017
03044017
Other identifier(s)
2-s2.0-84884975247
Rights
Mahidol University
Rights Holder(s)
SCOPUS
Bibliographic Citation
Veterinary Parasitology. Vol.197, No.3-4 (2013), 447-454
Suggested Citation
Rapeeporn Kumnuan, Sittiporn Pattaradilokrat, Kamlang Chumpolbanchorn, Suntorn Pimnon, Somphong Narkpinit, Pongchai Harnyuttanakorn, Tawee Saiwichai In vivo transmission blocking activities of artesunate on the avian malaria parasite Plasmodium gallinaceum. Veterinary Parasitology. Vol.197, No.3-4 (2013), 447-454. doi:10.1016/j.vetpar.2013.07.024 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/31855
Research Projects
Organizational Units
Authors
Journal Issue
Thesis
Title
In vivo transmission blocking activities of artesunate on the avian malaria parasite Plasmodium gallinaceum
Other Contributor(s)
Abstract
Infection and transmission of the avian malaria parasite Plasmodium gallinaceum in domestic chickens is associated with high economic burden and presents a major challenge to poultry industry in South East Asia. Development of drugs targeting both asexual blood stage parasites and sexual stages of the avian malarias will be beneficial for malaria treatment and eradication. However, current drugs recommended for treatment of the avian malaria parasites target specifically the asexual blood stage parasites, but have little or no impact to the gametocytes, the major target for development of transmission-blocking strategies. In the present work, we established a simple procedure to evaluate gametocytocidal and transmission blocking activities in a P. gallinaceum-avian model. The assays involved administration of seven consecutive daily doses of test compounds into P. gallinaceum-infected chickens with 10% parasitaemia and 1% gametocytaemia. Our studies indicated that intramuscular injection with seven daily low doses (the minimum effective dose of 10. mg/kg) of artesunate blocked the gametocyte production and transmission to the mosquito vector Aedes aegypti. This assay can be further applicable for testing new compounds against P. gallinaceum and for other parasitic protozoa infecting birds. © 2013 Elsevier B.V.