Publication: Extra-tumoral breast tissue in breast cancer patients: Variations with steroid contraceptive use
Issued Date
2006-06-01
Resource Type
ISSN
10970215
00207136
00207136
Other identifier(s)
2-s2.0-33646367649
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Mahidol University
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SCOPUS
Bibliographic Citation
International Journal of Cancer. Vol.118, No.11 (2006), 2827-2831
Suggested Citation
Tone B.Aaman Vamre, Helge Stalsberg, David B. Thomas, G. Berry, R. Maclennan, R. Shearman, T. Jelihovsky, J. Cooper Booth, R. Molina, L. Martinez, O. Salas, A. Dabacens, Cheng Zhiheng, Tao Yun, Hu Yong Wei, A. Cuadros, N. Aristizabal, K. Ebeling, P. Nishan, D. Kunde, B. Modan, E. Ron, E. Alfandary, J. G. Mati, P. Kenya, A. Kungu, D. Gatei, H. Rodriguez Cuevas, S. Benavides Salazar, A. Palet, P. Ontiveros, R. A. Apelo, J. R. De La Cruz, J. Baens, B. Javier, Suporn Silpisornkosol, Tieng Pardthaisong, Nimit Martin, Choti Theetranont, Banpot Boosiri, Supawat Chutivongse, Pramuan Virutamasen, Chansuda Wongsrichanalai, Prasarn Jimakorn, Supom Koetsawang, Daungdao Rachawat, Nivat Chantarakul, R. M. Ray, E. A. Noonan, S. Holck Extra-tumoral breast tissue in breast cancer patients: Variations with steroid contraceptive use. International Journal of Cancer. Vol.118, No.11 (2006), 2827-2831. doi:10.1002/ijc.21697 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/23037
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Title
Extra-tumoral breast tissue in breast cancer patients: Variations with steroid contraceptive use
Author(s)
Tone B.Aaman Vamre
Helge Stalsberg
David B. Thomas
G. Berry
R. Maclennan
R. Shearman
T. Jelihovsky
J. Cooper Booth
R. Molina
L. Martinez
O. Salas
A. Dabacens
Cheng Zhiheng
Tao Yun
Hu Yong Wei
A. Cuadros
N. Aristizabal
K. Ebeling
P. Nishan
D. Kunde
B. Modan
E. Ron
E. Alfandary
J. G. Mati
P. Kenya
A. Kungu
D. Gatei
H. Rodriguez Cuevas
S. Benavides Salazar
A. Palet
P. Ontiveros
R. A. Apelo
J. R. De La Cruz
J. Baens
B. Javier
Suporn Silpisornkosol
Tieng Pardthaisong
Nimit Martin
Choti Theetranont
Banpot Boosiri
Supawat Chutivongse
Pramuan Virutamasen
Chansuda Wongsrichanalai
Prasarn Jimakorn
Supom Koetsawang
Daungdao Rachawat
Nivat Chantarakul
R. M. Ray
E. A. Noonan
S. Holck
Helge Stalsberg
David B. Thomas
G. Berry
R. Maclennan
R. Shearman
T. Jelihovsky
J. Cooper Booth
R. Molina
L. Martinez
O. Salas
A. Dabacens
Cheng Zhiheng
Tao Yun
Hu Yong Wei
A. Cuadros
N. Aristizabal
K. Ebeling
P. Nishan
D. Kunde
B. Modan
E. Ron
E. Alfandary
J. G. Mati
P. Kenya
A. Kungu
D. Gatei
H. Rodriguez Cuevas
S. Benavides Salazar
A. Palet
P. Ontiveros
R. A. Apelo
J. R. De La Cruz
J. Baens
B. Javier
Suporn Silpisornkosol
Tieng Pardthaisong
Nimit Martin
Choti Theetranont
Banpot Boosiri
Supawat Chutivongse
Pramuan Virutamasen
Chansuda Wongsrichanalai
Prasarn Jimakorn
Supom Koetsawang
Daungdao Rachawat
Nivat Chantarakul
R. M. Ray
E. A. Noonan
S. Holck
Other Contributor(s)
UiT Norges Arktiske Universitet
Fred Hutchinson Cancer Research Center
The University of Sydney
Hospital Jose Joaquin Aguirre
Hospital del Salvador
Shanghai Institute of Planned Parenthood Research
Hospital Universitario
Akademie der Wissenschaften der DDR
Chaim Sheba Medical Center Israel
University of Nairobi
Hospital General de Mexico
University of the Philippines Manila
Chiang Mai University
Chulalongkorn University
Mahidol University
Organisation Mondiale de la Sante
Development and Research Training in Human Reproduction
Fred Hutchinson Cancer Research Center
The University of Sydney
Hospital Jose Joaquin Aguirre
Hospital del Salvador
Shanghai Institute of Planned Parenthood Research
Hospital Universitario
Akademie der Wissenschaften der DDR
Chaim Sheba Medical Center Israel
University of Nairobi
Hospital General de Mexico
University of the Philippines Manila
Chiang Mai University
Chulalongkorn University
Mahidol University
Organisation Mondiale de la Sante
Development and Research Training in Human Reproduction
Abstract
The association between oral contraceptive (OC) use and benign breast changes in extra-tumoral breast tissue was studied histologically in 1,503 breast cancer patients from The WHO Collaborative Study of Neoplasia and Steroid Contraceptives. The occurrence of ductal hyperplasia, ductal atypia, sclerosing adenosis, cysts, apocrine metaplasia, apocrine hyperplasia, apocrine atypia, adenosis, lobular atypia, duct ectasia, calcifications, inflammatory reaction, lactational metaplasia and a high epithelial-stromal ratio was graded semi-quantitatively. Prevalence odds ratio (POR) for each histologic variable was calculated by logistic regression analyses. Patients who had ever used OC had lower occurrence of ductal hyperplasia than never users (POR 0.72 (95% CI 0.52-0.99)). Current use and more than 8 years of use was also associated with a lower prevalence of ductal hyperplasia (POR 0.40 (0.20-0.81) and POR 0.33 (0.17-0.64), respectively). Age > 35 years at first use was associated with increased prevalence of ductal carcinoma in situ (POR 2.15 (1.05-4.40)), but not of atypical ductal hyperplasia. Our results show that the effects of OC use on ductal hyperplasia in non-neoplastic breast tissue of breast cancer patients are similar to what others have found in patients with benign breast disease only. The increased prevalence of extra-tumoral ductal carcinoma in situ in breast cancer patients who started OC use at high age may possibly be explained by a longer preinvasive phase in these patients. © 2005 Wiley-Liss, Inc.