Publication: Annular leukocytoclastic vasculitis associated with anti-tuberculosis medications: a case report
Issued Date
2013
Resource Type
Language
eng
Rights
Mahidol University
Rights Holder(s)
BioMed Central
Bibliographic Citation
Journal of Medical Case Reports 2013. Vol. 7, (2013), 34
Suggested Citation
Kumutnart Chanprapaph, Wanjarus Roongpisuthipong, Kunlawat Thadanipon Annular leukocytoclastic vasculitis associated with anti-tuberculosis medications: a case report. Journal of Medical Case Reports 2013. Vol. 7, (2013), 34. doi:10.1186/1752-1947-7-34 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/2697
Research Projects
Organizational Units
Authors
Journal Issue
Thesis
Title
Annular leukocytoclastic vasculitis associated with anti-tuberculosis medications: a case report
Abstract
Introduction: Anti-tuberculosis drug-induced cutaneous leukocytoclastic vasculitis has been rarely reported. To the
best of our knowledge, this is the first reported case of annular leukocytoclastic vasculitis associated with
anti-tuberculosis drug administration.
Case presentation: We report a case of annular leukocytoclastic vasculitis induced by anti-tuberculosis medication.
A 62-year-old Thai man presented to our facility with a generalized exanthematous rash on his trunk and
extremities that resolved shortly afterwards. Subsequently, he developed multiple, erythematous-to-purplish,
non-blanchable macules and papules with an annular arrangement on his extremities. The skin rash occurred after
two weeks of anti-tuberculosis medication. The histopathology of the purpuric skin lesion was consistent with
leukocytoclastic vasculitis. The skin lesion improved after discontinuation of the anti-tuberculosis drugs and
treatment with oral antihistamine and topical corticosteroid drugs. Streptomycin, ethambutol and ofloxacin were
administered as second-line anti-tuberculosis therapy during his hospitalization. No adverse reactions were
observed.
Conclusions: Leukocytoclastic vasculitis should be considered in the differential diagnosis of annular
non-blanchable macules and papules. Although rare, anti-tuberculosis drugs should be considered potential causes
of drug-induced annular leukocytoclastic vasculitis.