Publication: Flavors of Flaviviral RNA Structure: towards an Integrated View of RNA Function from Translation through Encapsidation
Issued Date
2019-08-01
Resource Type
ISSN
15211878
02659247
02659247
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2-s2.0-85069472611
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Mahidol University
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SCOPUS
Bibliographic Citation
BioEssays. Vol.41, No.8 (2019)
Suggested Citation
Kenneth Hodge, Maliwan Kamkaew, Trairak Pisitkun, Sarin Chimnaronk Flavors of Flaviviral RNA Structure: towards an Integrated View of RNA Function from Translation through Encapsidation. BioEssays. Vol.41, No.8 (2019). doi:10.1002/bies.201900003 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/50112
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Title
Flavors of Flaviviral RNA Structure: towards an Integrated View of RNA Function from Translation through Encapsidation
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Abstract
© 2019 WILEY Periodicals, Inc. For many viruses, RNA is the holder of genetic information and serves as the template for both replication and translation. While host and viral proteins play important roles in viral decision-making, the extent to which viral RNA (vRNA) actively participates in translation and replication might be surprising. Here, the focus is on flaviviruses, which include common human scourges such as dengue, West Nile, and Zika viruses, from an RNA-centric viewpoint. In reviewing more recent findings, an attempt is made to fill knowledge gaps and revisit some canonical views of vRNA structures involved in replication. In particular, alternative views are offered on the nature of the flaviviral promoter and genome cyclization, and the feasibility of refining in vitro-derived models with modern RNA probing and sequencing methods is pointed out. By tracing vRNA structures from translation through encapsidation, a dynamic molecule closely involved in the self-regulation of viral replication is revealed.