Publication: Sennetsu neorickettsiosis: A probable fish-borne cause of fever rediscovered in Laos
1
Issued Date
2009-08-01
Resource Type
ISSN
00029637
Other identifier(s)
2-s2.0-68549139017
Rights
Mahidol University
Rights Holder(s)
SCOPUS
Bibliographic Citation
American Journal of Tropical Medicine and Hygiene. Vol.81, No.2 (2009), 190-194
Suggested Citation
Paul N. Newton, Jean Marc Rolain, Bouachanh Rasachak, Mayfong Mayxay, Khamtanh Vathanatham, Piseth Seng, Rattanaphone Phetsouvanh, Te Thammavong, Jamaayah Zahidi, Yupin Suputtamongkol, Bounkong Syhavong, Didier Raoult Sennetsu neorickettsiosis: A probable fish-borne cause of fever rediscovered in Laos. American Journal of Tropical Medicine and Hygiene. Vol.81, No.2 (2009), 190-194. Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/27687
Research Projects
Organizational Units
Authors
Journal Issue
Thesis
Title
Sennetsu neorickettsiosis: A probable fish-borne cause of fever rediscovered in Laos
Abstract
Neorickettsia sennetsu has been described from Japan and Malaysia, causing a largely forgotten infectious mononucleosis-like disease. Because it is believed to be contracted from eating raw fish, frequently consumed in the Lao PDR, we looked for evidence of N. sennetsu among Lao patients and fish. A buffy coat from 1 of 91 patients with undifferentiated fever was positive by 16S rRNA amplification and sequencing and real-time polymerase chain reactions (PCR) targeting two N. sennetsu genes. Lao blood donors and patients with fever, hepatitis, or jaundice (N = 1,132) had a high prevalence (17%) of immunofluorescence assay IgG anti-N. sennetsu antibodies compared with 4% and 0% from febrile patients (N = 848) in Thailand and Malaysia, respectively. We found N. sennetsu DNA by PCR, for the first time, in a fish (Anabas testudineus). These data suggest that sennetsu may be an under-recognized cause of fever and are consistent with the hypothesis that it may be contracted from eating raw fish. Copyright © 2009 by The American Society of Tropical Medicine and Hygiene.