Publication: Genetic diversity of Plasmodium vivax in Kolkata, India.
Accepted Date
2006-08-14
Issued Date
2006-08-14
Copyright Date
2006
Resource Type
Language
eng
ISSN
1475-2875 (electronic)
Rights
Mahidol University
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BioMed Central
Bibliographic Citation
Kim JR, Imwong M, Nandy A, Chotivanich K, Nontprasert A, Tonomsing N, et al. Genetic diversity of Plasmodium vivax in Kolkata, India. Malar J. 2006 Aug 14;5:71.
Suggested Citation
Kim, Jung-Ryong, Mallika Imwong, มัลลิกา อิ่มวงศ์, Nandy, Amitabha, Kesinee Chotivanich, เกศินี โชติวานิช, Apichart Nontprasert, อภิชาต นนท์ประเสริฐ, Naowarat Tonomsing, Maji, Ardhendu, Addy, Manjulika, Day, Nick P.J., White, Nicholas J., Sasithon Pukrittayakamee, ศศิธร ผู้กฤตยาคามี Genetic diversity of Plasmodium vivax in Kolkata, India.. Kim JR, Imwong M, Nandy A, Chotivanich K, Nontprasert A, Tonomsing N, et al. Genetic diversity of Plasmodium vivax in Kolkata, India. Malar J. 2006 Aug 14;5:71.. doi:10.1186/1475-2875-5-71 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/711
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Title
Genetic diversity of Plasmodium vivax in Kolkata, India.
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Abstract
BACKGROUND: Plasmodium vivax malaria accounts for approximately 60% of malaria
cases in Kolkata, India. There has been limited information on the genotypic
polymorphism of P. vivax in this malaria endemic area. Three highly polymorphic
and single copy genes were selected for a study of genetic diversity in Kolkata
strains.
METHODS: Blood from 151 patients with P. vivax infection diagnosed in Kolkata
between April 2003 and September 2004 was genotyped at three polymorphic loci:
the P. vivax circumsporozoite protein (pvcs), the merozoite surface protein 1
(pvmsp1) and the merozoite surface protein 3-alpha (pvmsp3-alpha).
RESULTS: Analysis of these three genetic markers revealed that P. vivax
populations in Kolkata are highly diverse. A large number of distinguishable
alleles were found from three genetic markers: 11 for pvcs, 35 for pvmsp1 and 37
for pvmsp3-alpha. These were, in general, randomly distributed amongst the
isolates. Among the 151 isolates, 142 unique genotypes were detected the
commonest genotype at a frequency of less than 2% (3/151). The overall rate of
mixed genotype infections was 10.6%.
CONCLUSION: These results indicate that the P. vivax parasite population is
highly diverse in Kolkata, despite the low level of transmission. The genotyping
protocols used in this study may be useful for differentiating re-infection from
relapse and recrudescence in studies assessing of malarial drug efficacy in vivax
malaria.