Polymeric micelles for pulmonary drug delivery: a comprehensive review

Abstract

Abstract: Respiratory diseases have remained one of the most common diseases worldwide, in which oral and intravenous administration are the most common treatment routes. However, these administrative routes face various difficulties in reaching local pulmonary targets, possessing low efficacy, and have high risk of systemic side effects. To solve these issues, polymeric micelles represent an effective approach. These nano-ranged delivery systems can encapsulate and protect poorly water-soluble drugs, enhance drug targeting to the lung, reduce side effects, and improve drug efficacy via inhalation route. In this review, the importance of rational design was highlighted by summarizing the recent progress on the development of polymeric micelles in pulmonary delivery. Emphasis is also placed on the different types and preparations, as well as ideal properties and advantages of polymeric micelles for pulmonary route. Graphic abstract: [Figure not available: see fulltext.].