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Correlation of Vitamin D binding protein gene polymorphism and protein levels in chronic obstructive pulmonary disease compared with non-chronic obstructive pulmonary disease subjects

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dc.contributor.authorBenjamas Chuaychooen_US
dc.contributor.authorRungsunn Tungtrongchitren_US
dc.contributor.authorWantanee Kriengsinyosen_US
dc.contributor.authorSiriporn Tuntipopipaten_US
dc.contributor.authorNattira On-Nomen_US
dc.contributor.authorChaowanee Chupeerachen_US
dc.contributor.otherMahidol Universityen_US
dc.contributor.otherFaculty of Medicine, Siriraj Hospital, Mahidol Universityen_US
dc.date.accessioned2019-08-23T10:28:19Z
dc.date.available2019-08-23T10:28:19Z
dc.date.issued2018-09-01en_US
dc.description.abstract© 2018 Future Medicine Ltd. Aim: The risk of vitamin D binding protein (DBP) variations in chronic obstructive pulmonary disease (COPD) compared with non-COPD Thai males were investigated. Materials & methods: The rs7041 and rs4588 polymorphisms of the DBP gene and protein level were measured in 136 COPD and 68 non-COPD Thai males. Results: In the COPD group, GC1-1 gave increased forced expiratory volume at 1 s % predicted compared with GC1-2 but with no significant difference. Significantly lower average DBP serum levels were observed in COPD than non-COPD subjects. Positive correlation between serum DBP and forced expiratory volume at 1 s % predicted was observed in non-COPD subjects. Discussion & conclusion: DBP variations might be associated with risk factors in COPD caused by both inflammatory and vitamin D circulation processes.en_US
dc.identifier.citationPersonalized Medicine. Vol.15, No.5 (2018), 371-379en_US
dc.identifier.doi10.2217/pme-2018-0005en_US
dc.identifier.issn1744828Xen_US
dc.identifier.issn17410541en_US
dc.identifier.other2-s2.0-85054626575en_US
dc.identifier.urihttps://repository.li.mahidol.ac.th/handle/20.500.14594/45055
dc.rightsMahidol Universityen_US
dc.rights.holderSCOPUSen_US
dc.source.urihttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85054626575&origin=inwarden_US
dc.subjectBiochemistry, Genetics and Molecular Biologyen_US
dc.subjectPharmacology, Toxicology and Pharmaceuticsen_US
dc.titleCorrelation of Vitamin D binding protein gene polymorphism and protein levels in chronic obstructive pulmonary disease compared with non-chronic obstructive pulmonary disease subjectsen_US
dc.typeArticleen_US
dspace.entity.typePublication
mu.datasource.scopushttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85054626575&origin=inwarden_US

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