Publication: Plant anticancer agents, XLVIII. New cytotoxic flavonoids from muntingia calabura roots
Issued Date
1991-01-01
Resource Type
ISSN
15206025
01633864
01633864
Other identifier(s)
2-s2.0-0026083261
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Mahidol University
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SCOPUS
Bibliographic Citation
Journal of Natural Products. Vol.54, No.1 (1991), 196-206
Suggested Citation
Norito Kaneda, John M. Pezzuto, D. Doel Soejarto, A. Douglas Kinghorn, Norman R. Farnsworth, Thawatchai Santisuk, Patoomratana Tuchinda, Jinda Udchachon, Vichai Reutrakul Plant anticancer agents, XLVIII. New cytotoxic flavonoids from muntingia calabura roots. Journal of Natural Products. Vol.54, No.1 (1991), 196-206. doi:10.1021/np50073a019 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/22012
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Title
Plant anticancer agents, XLVIII. New cytotoxic flavonoids from muntingia calabura roots
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Abstract
From a cytotoxic Et2O soluble extract of Muntingia calabura roots, twelve new flavonoids were isolated, constituting seven flavans 1–7, three flavones 8, 10, and 12, and two biflavans 9 and 11. The structures of compounds 1–12 were established by the interpretation of spectral data, with the nmr assignments of these constituents being based on1H−1H COSY,1H−13C HETCOR, and selective INEPT experiments. This is the first report of the occurrence of 7,8-di-O-substituted flavans, biflavans, and flavones. Most of the isolates demonstrated cytotoxic activity when tested against cultured P-388 cells, with the flavans being more active than the flavones. Furthermore, certain of these structurally related flavonoids exhibited somewhat selective activities when evaluated with a number of human cancer cell lines. © 1991, American Chemical Society. All rights reserved.