Publication: Effect of polysulfonate resins and direct compression fillers on multiple-unit sustained-release dextromethorphan resinate tablets
Issued Date
2005-09-30
Resource Type
ISSN
15309932
15309932
15309932
DOI
Other identifier(s)
2-s2.0-27744532702
Rights
Mahidol University
Rights Holder(s)
SCOPUS
Bibliographic Citation
AAPS PharmSciTech. Vol.6, No.2 (2005)
Suggested Citation
Thaned Pongjanyakul, Aroonsri Priprem, Padungkwan Chitropas, Satit Puttipipatkhachorn Effect of polysulfonate resins and direct compression fillers on multiple-unit sustained-release dextromethorphan resinate tablets. AAPS PharmSciTech. Vol.6, No.2 (2005). doi:10.1208/pt060228 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/16293
Research Projects
Organizational Units
Authors
Journal Issue
Thesis
Title
Effect of polysulfonate resins and direct compression fillers on multiple-unit sustained-release dextromethorphan resinate tablets
Other Contributor(s)
Abstract
The purpose of this work was to investigate the effect of different polysulfonate resins and direct compression fillers on physical properties of multiple-unit sustained-release dextromethorphan (DMP) tablets. DMP resinates were formed by a complexation of DMP and strong cation exchange resins, Dowex 50 W and Amberlite IRP69. The tablets consisted of the DMP resinates and direct compression fillers, such as microcrystalline cellulose (MCC), dicalcium phosphate dihydrate (DCP), and spray-dried rice starch (SDRS). Physical properties of tablets, such as hardness, disintegration time, and in vitro release, were investigated. A good performance of the tablets was obtained when MCC or SDRS was used. The use of rod-like and plate-like particles of Amberlite IRP69 caused a statistical decrease in tablet hardness, whereas good tablet hardness was obtained when spherical particle of Dowex 50 W was used. The plastic deformation of the fillers, such as MCC and SDRS, caused a little change in the release of DMP. A higher release rate constant was found in the tablets containing DCP and Dowex 50 W, indicating the fracture of the resinates under compression, which was attributable to the fragmentation of DCP. However, the release of DMP from the tablets using Amberlite IRP69 was not significantly changed because of the higher degree of cross-linking of the resinates, which exhibited more resistance to deformation under compression. In conclusion, the properties of polysulfonate resin, such as particle shape and degree of cross-linking, and the deformation under compaction of fillers affect the physical properties and the drug release of the resinate tablets. Copyright ©2003. All Rights Reserved.