Linear growth of prepubertal asthmatic Thai children receiving long-term inhaled corticosteroids

Abstract

Background: Long-term inhaled corticosteroids are recommended in persistent asthma in children. The aim of this study was to determine the growth rate of asthmatic Thai children who received long-term inhaled corticosteroids. Method: This controlled clinical trial was carried out on 145 prepubertal asthmatic Thai children, 81 in the study group (the group who received long-term inhaled corticosteroids) and 64 in the control group. Results: The mean age of the patients when the study began was 5.9 years in the study group and 4.7 years in the control group. The average dose of inhaled corticosteroids used was 300 μg/day. The average duration overtime of inhaled corticosteroid usage was 2 years (9 months - 5 years). The study showed that inhaled corticosteroids (300 gg/day for 9-60 months) have no significant effects on growth rate. From linear regression analysis, the factors that influenced the growth rate of asthmatic patients were the severity of the asthma and the age of the patients when nasal corticosteroids were started. Insulin-like Growth Factor 1 (IGF 1) and Insulin-like Growth Factor Binding Protein 3 (IGFBP 3), were measured in 7 patients in the study group and 5 in the control group. All were normal, the height standard deviation score (Ht.SDS) was below average. Conclusions: The average dose of inhaled corticosteroids (300 μg/day for 9 months) has no significant effects on the growth rate of prepubertal asthmatic Thai children.