Publication:
Mechanical power of ventilation is associated with mortality in critically ill patients: an analysis of patients in two observational cohorts

Issued Date

2018-11-01

Resource Type

Article

ISSN

14321238
03424642

DOI

10.1007/s00134-018-5375-6

Other identifier(s)

2-s2.0-85054565031

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Mahidol University

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SCOPUS

Bibliographic Citation

Intensive Care Medicine. Vol.44, No.11 (2018), 1914-1922

Suggested Citation

Ary Serpa Neto, Rodrigo Octavio Deliberato, Alistair E.W. Johnson, Lieuwe D. Bos, Pedro Amorim, Silvio Moreto Pereira, Denise Carnieli Cazati, Ricardo L. Cordioli, Thiago Domingos Correa, Tom J. Pollard, Guilherme P.P. Schettino, Karina T. Timenetsky, Leo A. Celi, Paolo Pelosi, Marcelo Gama de Abreu, Marcus J. Schultz Mechanical power of ventilation is associated with mortality in critically ill patients: an analysis of patients in two observational cohorts. Intensive Care Medicine. Vol.44, No.11 (2018), 1914-1922. doi:10.1007/s00134-018-5375-6 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/46227

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Title

Mechanical power of ventilation is associated with mortality in critically ill patients: an analysis of patients in two observational cohorts

Author(s)

Ary Serpa Neto
 Rodrigo Octavio Deliberato
 Alistair E.W. Johnson
 Lieuwe D. Bos
 Pedro Amorim
 Silvio Moreto Pereira
 Denise Carnieli Cazati
 Ricardo L. Cordioli
 Thiago Domingos Correa
 Tom J. Pollard
 Guilherme P.P. Schettino
 Karina T. Timenetsky
 Leo A. Celi
 Paolo Pelosi
 Marcelo Gama de Abreu
 Marcus J. Schultz

Other Contributor(s)

Ospedale Policlinico San Martino
 Beth Israel Deaconess Medical Center
 Dresden University Faculty of Medicine and University Hospital Carl Gustav Carus
 Università degli Studi di Genova
 Massachusetts Institute of Technology
 Hospital Israelita Albert Einstein
 Mahidol University
 Amsterdam UMC - University of Amsterdam

Abstract

© 2018, Springer-Verlag GmbH Germany, part of Springer Nature and ESICM. Purpose: Mechanical power (MP) may unify variables known to be related to development of ventilator-induced lung injury. The aim of this study is to examine the association between MP and mortality in critically ill patients receiving invasive ventilation for at least 48 h. Methods: This is an analysis of data stored in the databases of the MIMIC–III and eICU. Critically ill patients receiving invasive ventilation for at least 48 h were included. The exposure of interest was MP. The primary outcome was in-hospital mortality. Results: Data from 8207 patients were analyzed. Median MP during the second 24 h was 21.4 (16.2–28.1) J/min in MIMIC-III and 16.0 (11.7–22.1) J/min in eICU. MP was independently associated with in-hospital mortality [odds ratio per 5 J/min increase (OR) 1.06 (95% confidence interval (CI) 1.01–1.11); p = 0.021 in MIMIC-III, and 1.10 (1.02–1.18); p = 0.010 in eICU]. MP was also associated with ICU mortality, 30-day mortality, and with ventilator-free days, ICU and hospital length of stay. Even at low tidal volume, high MP was associated with in-hospital mortality [OR 1.70 (1.32–2.18); p < 0.001] and other secondary outcomes. Finally, there is a consistent increase in the risk of death with MP higher than 17.0 J/min. Conclusion: High MP of ventilation is independently associated with higher in-hospital mortality and several other outcomes in ICU patients receiving invasive ventilation for at least 48 h.

Keyword(s)

Medicine

Availability

URI

https://repository.li.mahidol.ac.th/handle/20.500.14594/46227

Collections

Scopus 2018