Publication: FTO polymorphisms in oceanic populations
Issued Date
2007-12-01
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ISSN
14345161
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2-s2.0-36448953082
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Mahidol University
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SCOPUS
Bibliographic Citation
Journal of Human Genetics. Vol.52, No.12 (2007), 1031-1035
Suggested Citation
Jun Ohashi, Izumi Naka, Ryosuke Kimura, Kazumi Natsuhara, Taro Yamauchi, Takuro Furusawa, Minato Nakazawa, Yuji Ataka, Jintana Patarapotikul, Pornlada Nuchnoi, Katsushi Tokunaga, Takafumi Ishida, Tsukasa Inaoka, Yasuhiro Matsumura, Ryutaro Ohtsuka FTO polymorphisms in oceanic populations. Journal of Human Genetics. Vol.52, No.12 (2007), 1031-1035. doi:10.1007/s10038-007-0198-2 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/24077
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Title
FTO polymorphisms in oceanic populations
Abstract
It has been suggested that Neel's "thrifty genotype" model may account for high body weights in some Oceanic populations, which presumably arose in modern times. In European populations, common variants (rs1421085-C, rs17817449-G, and rs9939609-A) in the fat mass and obesity (FTO associated) were recently found to be associated with body mass index (BMI) or obesity. In this study, we investigated the population frequencies of these variants in six Oceanic populations (Melanesians, Micronesians, and Polynesians) and tested for an association with BMI. Unlike European populations, the Oceanic populations displayed no significant association between the FTO polymorphisms and BMI. These variants were in strong linkage disequilibrium. The population frequencies ranged between 4.2 and 30.3% in the six Oceanic populations, and were similar to those in southeast and east Asian populations. Our study of the FTO polymorphisms has generated no evidence to support the thrifty genotype hypothesis for Oceanic populations. © 2007 The Japan Society of Human Genetics and Springer.