Publication: Diffusion-weighted chemical shift imaging of human brain metabolites at 7T
Issued Date
2015-06-01
Resource Type
ISSN
15222594
07403194
07403194
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2-s2.0-84929630421
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Mahidol University
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SCOPUS
Bibliographic Citation
Magnetic Resonance in Medicine. Vol.73, No.6 (2015), 2053-2061
Suggested Citation
Ayse Ece Ercan, Aranee Techawiboonwong, Maarten J. Versluis, Andrew G. Webb, Itamar Ronen Diffusion-weighted chemical shift imaging of human brain metabolites at 7T. Magnetic Resonance in Medicine. Vol.73, No.6 (2015), 2053-2061. doi:10.1002/mrm.25346 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/36418
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Title
Diffusion-weighted chemical shift imaging of human brain metabolites at 7T
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Abstract
© 2014 Wiley Periodicals, Inc. Purpose Diffusion-weighted chemical shift imaging (DW-CSI) of brain metabolites poses significant challenges associated with the acquisition of spectroscopic data in the presence of strong diffusion weighting gradients. We present a reproducible DW-CSI acquisition and processing scheme that addresses most of the potential sources of instability and provides reproducible and anatomically meaningful diffusion-weighted and apparent diffusion coefficient (ADC) metabolite maps. Methods A real-time navigator-based acquisition scheme was used, allowing instantaneous reacquisition of corrupted k-space data and postprocessing correction of gradient-induced phase fluctuations. Eddy current correction based on residual water resonance was implemented and improved the quality of the data significantly. Results Highly reproducible diffusion-weighted metabolite maps of three highest concentration brain metabolites are shown. The navigator-based accept/reject strategy and the postacquisition corrections improved the stability of the DW-CSI signal and the reproducibility of the resulting DW-CSI maps significantly. The metabolite ADC values could be related to the underlying tissue cellular composition. Conclusion Robust investigation of DW-CSI of brain metabolites is feasible and may provide information complementary to that obtained from more sensitive but less specific methods such as diffusion tensor imaging. Magn Reson Med 73:2053-2061, 2015.