Publication: Diagnostic value of buffy coat preparation in dengue hemorrhagic fever
7
Issued Date
1979-12-01
Resource Type
ISSN
00383619
Other identifier(s)
2-s2.0-0018581678
Rights
Mahidol University
Rights Holder(s)
SCOPUS
Bibliographic Citation
Southeast Asian Journal of Tropical Medicine and Public Health. Vol.10, No.1 (1979), 7-12
Suggested Citation
V. Suvatte, M. Longsaman Diagnostic value of buffy coat preparation in dengue hemorrhagic fever. Southeast Asian Journal of Tropical Medicine and Public Health. Vol.10, No.1 (1979), 7-12. Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/13225
Research Projects
Organizational Units
Authors
Journal Issue
Thesis
Title
Diagnostic value of buffy coat preparation in dengue hemorrhagic fever
Author(s)
Other Contributor(s)
Abstract
Examination of the buffy coat preparation is a simple, rapid diagnostic acid for the early diagnosis of dengue hemorrhagic fever (DHF). The presence of many transformed lymphocytes, usually 20-50 percent, during the first few days of fever is a unique finding especially during a secondary infection. Similar findings are absent during the early phase of illness in other viral infections. The buffy coat appearance in DHF is also clearly different from those in patients with bacterial infections, which show many polymorphonuclear leukocytes containing toxic granules and vacuoles. The early buffy coat diagnosis in 320 cases of DHF correlated well with the later serologic diagnosis. The buffy coat diagnosis of secondary DHF was correct in 94.2% of cases as early as the third day of fever. This technique has proven to be clinically useful for early screening test of secondary DHF in Southeast Asian countries. The observation of many transformed lymphocytes in the peripheral blood of DHF patients also offer some insight into the pathogenesis of this condition.