Publication: Role of domestic ducks in the propagation and biological evolution of highly pathogenic H5N1 influenza viruses in Asia
Issued Date
2005-07-26
Resource Type
ISSN
00278424
Other identifier(s)
2-s2.0-23044502533
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Mahidol University
Rights Holder(s)
SCOPUS
Bibliographic Citation
Proceedings of the National Academy of Sciences of the United States of America. Vol.102, No.30 (2005), 10682-10687
Suggested Citation
D. J. Hulse-Post, K. M. Sturm-Ramirez, J. Humberd, P. Seiler, E. A. Govorkova, S. Krauss, C. Scholtissek, P. Puthavathana, C. Buranathai, T. D. Nguyen, H. T. Long, T. S P Naipospos, H. Chen, T. M. Ellis, Y. Guan, J. S M Peiris, R. G. Webster Role of domestic ducks in the propagation and biological evolution of highly pathogenic H5N1 influenza viruses in Asia. Proceedings of the National Academy of Sciences of the United States of America. Vol.102, No.30 (2005), 10682-10687. doi:10.1073/pnas.0504662102 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/16313
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Title
Role of domestic ducks in the propagation and biological evolution of highly pathogenic H5N1 influenza viruses in Asia
Other Contributor(s)
St. Jude Children Research Hospital
Mahidol University
Thailand National Institute of Animal Health
National Institute of Veterinary Research Hanoi
National Institute of Hygiene and Epidemiology Hanoi
Ministry of Agriculture, Indonesia
Chinese Academy of Agricultural Sciences
Fisheries
Shantou University, Medical College (SUMC)
The University of Hong Kong
Mahidol University
Thailand National Institute of Animal Health
National Institute of Veterinary Research Hanoi
National Institute of Hygiene and Epidemiology Hanoi
Ministry of Agriculture, Indonesia
Chinese Academy of Agricultural Sciences
Fisheries
Shantou University, Medical College (SUMC)
The University of Hong Kong
Abstract
Wild waterfowl, including ducks, are natural hosts of influenza A viruses. These viruses rarely caused disease in ducks until 2002, when some H5N1 strains became highly pathogenic. Here we show that these H5N1 viruses are reverting to nonpathogenicity in ducks. Ducks experimentally infected with viruses isolated between 2003 and 2004 shed virus for an extended time (up to 17 days), during which variant viruses with low pathogenicity were selected. These results suggest that the duck has become the "Trojan horse" of Asian H5N1 influenza viruses. The ducks that are unaffected by infection with these viruses continue to circulate these viruses, presenting a pandemic threat. © 2005 by The National Academy of Sciences of the USA.