Publication: Polyketides and alkaloids from the marine-derived fungus Dichotomomyces cejpii F31-1 and the antiviral activity of scequinadoline A against dengue virus
Issued Date
2018-07-01
Resource Type
ISSN
16603397
Other identifier(s)
2-s2.0-85052025912
Rights
Mahidol University
Rights Holder(s)
SCOPUS
Bibliographic Citation
Marine Drugs. Vol.16, No.7 (2018)
Suggested Citation
Dong Lan Wu, Hou Jin Li, Duncan R. Smith, Janejira Jaratsittisin, Xia Fu Kai Ti Xia-Ke-Er, Wen Zhe Ma, Yong Wei Guo, Jun Dong, Juan Shen, De Po Yang, Wen Jian Lan Polyketides and alkaloids from the marine-derived fungus Dichotomomyces cejpii F31-1 and the antiviral activity of scequinadoline A against dengue virus. Marine Drugs. Vol.16, No.7 (2018). doi:10.3390/md16070229 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/47308
Research Projects
Organizational Units
Authors
Journal Issue
Thesis
Title
Polyketides and alkaloids from the marine-derived fungus Dichotomomyces cejpii F31-1 and the antiviral activity of scequinadoline A against dengue virus
Abstract
© 2018 by the authors. In our continuous chemical investigation on the marine-derived fungus Dichotomomyces cejpii F31-1, two new polyketides dichocetides B-C (1, 2), two new alkaloids dichotomocejs E-F (3, 4), and three known fumiquinozalines: scequinadoline A (5), quinadoline A (6), and scequinadoline E (7) were discovered from the culture broth and the mycelium in the culture medium, by the addition of L-tryptophan and L-phenylalanine. Their chemical structures were established by one dimensional (1D), two dimensional (2D) nuclear magnetic resonance (NMR) and high resolution mass spectrometry (HR-MS) data. Among them, scequinadoline A (5) exhibited significant inhibitory activity against dengue virus serotype 2 production by standard plaque assay, equivalent to the positive control andrographlide. Scequinadoline A (5) possesses the potential for further development as a dengue virus inhibitor.