Publication: Recombinant activated factor VII in children with acute bleeding resulting from liver failure and disseminated intravascular coagulation
Issued Date
2000-01-01
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ISSN
09575235
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2-s2.0-0034123522
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Mahidol University
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SCOPUS
Bibliographic Citation
Blood Coagulation and Fibrinolysis. Vol.11, No.4 SUPPL. 1 (2000)
Suggested Citation
Ampaiwan Chuansumrit, T. Chantarojanasiri, P. Isarangkura, S. Teeraratkul, S. Hongeng, P. Hathirat Recombinant activated factor VII in children with acute bleeding resulting from liver failure and disseminated intravascular coagulation. Blood Coagulation and Fibrinolysis. Vol.11, No.4 SUPPL. 1 (2000). doi:10.1097/00001721-200004001-00019 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/26311
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Title
Recombinant activated factor VII in children with acute bleeding resulting from liver failure and disseminated intravascular coagulation
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Abstract
Recombinant activated factor VII (rFVIIa) was given to three children with acute bleeding resulting from liver failure and disseminated intravascular coagulation. Cases I and II (girls aged 3 years and 6 years, respectively) were diagnosed with Dengue hemorrhagic fever and prolonged shock. Case III, a boy aged 9 months, underwent left lobe hepatectomy for a hepatoblastoma, during which 60% of his liver was removed. This case was complicated by myoglobinuria, liver and renal impairment and early disseminated intravascular coagulation. All three patients exhibited active bleeding. Cases I and II received rFVIIa combined with other blood component replacement, while Case III received rFVIIa as the only hemostatic agent. A bolus of 40-180 μg/kg b.w. was administered followed by 16.533 μg/kg b.w. per h continuous infusion. As a result, bleeding was controlled, the prothrombin time was shortened and FVII clotting activity was significantly increased. In conclusion, rFVIIa has shown some efficacy in controlling acute bleeding in children with liver failure and disseminated intravascular coagulation. (C) 2000 Lippincott Williams and Wilkins.