Publication: Beijing genotype of Mycobacterium tuberculosis is significantly associated with human immunodeficiency virus infection and multidrug resistance in cases of tuberculous meningitis
Issued Date
2006-11-01
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ISSN
00951137
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2-s2.0-33750954210
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Mahidol University
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SCOPUS
Bibliographic Citation
Journal of Clinical Microbiology. Vol.44, No.11 (2006), 3934-3939
Suggested Citation
Maxine Caws, Guy Thwaites, Kasia Stepniewska, Nguyen Thi Ngoc Lan, Nguyen Thi Hong Duyen, Nguyen Thi Phuong, Mai Nguyet Thu Huyen, Phan Minh Duy, Tran Huu Loc, Tran Thi Hong Chau, Dick Van Soolingen, Kristin Kremer, Nguyen Vinh Van Chau, Nguyen Tran Chinh, Jeremy Farrar Beijing genotype of Mycobacterium tuberculosis is significantly associated with human immunodeficiency virus infection and multidrug resistance in cases of tuberculous meningitis. Journal of Clinical Microbiology. Vol.44, No.11 (2006), 3934-3939. doi:10.1128/JCM.01181-06 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/23296
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Title
Beijing genotype of Mycobacterium tuberculosis is significantly associated with human immunodeficiency virus infection and multidrug resistance in cases of tuberculous meningitis
Abstract
Multidrug-resistant tuberculous meningitis is fatal without rapid diagnosis and use of second-line therapy. It is more common in human immunodeficiency virus (HIV)-positive patients. Beijing genotype strains of Mycobacterium tuberculosis are associated with drug resistance, particularly multidrug resistance, and their prevalence is increasing worldwide. The prevalence of Beijing genotype strains among Mycobacterium tuberculosis isolates from the cerebrospinal fluid of HIV-positive (n = 35) and HIV-negative (n = 187) patients in Ho Chi Minh City was determined. The Beijing genotype was significantly associated with HIV status (odds ratio [OR] = 2.95 [95% confidence interval {CI}, 1.38 to 6.44]; P = 0.016), resistance to any drug (OR = 3.34 [95% CI, 1.87 to 5.95]; P < 0.001) and multidrug resistance (Fisher's exact test; P = 0.001). The association of the Beijing genotype with drug resistance was independent of HIV status. This is the first report of Beijing genotype association with HIV status, which may be an association unique to tuberculous meningitis. Copyright © 2006, American Society for Microbiology. All Rights Reserved.