Publication: Secretory effect of prostaglandins on the rabbit lacrimal gland in vivo
Issued Date
1979-01-01
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ISSN
01614630
Other identifier(s)
2-s2.0-0018691426
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Mahidol University
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SCOPUS
Bibliographic Citation
Prostaglandines and Medicine. Vol.3, No.3 (1979), 185-192
Suggested Citation
C. Pholpramool Secretory effect of prostaglandins on the rabbit lacrimal gland in vivo. Prostaglandines and Medicine. Vol.3, No.3 (1979), 185-192. doi:10.1016/0161-4630(79)90102-2 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/13255
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Title
Secretory effect of prostaglandins on the rabbit lacrimal gland in vivo
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Abstract
Fluid secretion from the cannulated excretory duct of the rabbit lacrimal gland was collected in microcapillary pipette at 10 min intervals. Secretion rate and electrolyte concentrations (Na+, K+ and Cl-) in the lacrimal fluid samples were determined before and after injections of small doses of prostaglandins (PGE 1 , PGE 2 , PG F 1α , PGF 2α , 15 epi-PGF 2α , PGF 2β , PGA l & PGA 2 ) into the external maxillary artery. Only PGE 1 had a dose-dependent stimulatory effect on the lacrimal gland secretion. The maximum secretion rate which was induced by PGE 1 (25 μg/kg) was 7.2 ± 0.9 μl/10 min. Na + concentration in the fluid secretion stimulated by PGE 1 was increased; however, K + and Cl - concentrations were not changed. Pretreatment with atropine (50 μg/kg, I.A.) failed to prevent the stimulatory effect of low doses of PGE 1 . On the other hand, the secretory responses were abolished when propanolol (3 mg/kg, I.A.) was administered prior to PGEI. The results suggest that fluid secretion of the rabbit lacrimal gland in response to PGEI may be caused by excitation of the sympathetic ganglia and/or by direct action on β-receptors in the acinar cells. © 1979.