Publication:
The selective peroxisome proliferator-activated receptor alpha modulator (SPPARMα) paradigm: Conceptual framework and therapeutic potential

Issued Date

2019-06-04

Resource Type

Review

ISSN

14752840

DOI

10.1186/s12933-019-0864-7

Other identifier(s)

2-s2.0-85066822428

Rights

Mahidol University

Rights Holder(s)

SCOPUS

Bibliographic Citation

Cardiovascular Diabetology. Vol.18, No.1 (2019)

Suggested Citation

Jean Charles Fruchart, Raul D. Santos, Carlos Aguilar-Salinas, Masanori Aikawa, Khalid Al Rasadi, Pierre Amarenco, Philip J. Barter, Richard Ceska, Alberto Corsini, Jean Pierre Després, Patrick Duriez, Robert H. Eckel, Marat V. Ezhov, Michel Farnier, Henry N. Ginsberg, Michel P. Hermans, Shun Ishibashi, Fredrik Karpe, Tatsuhiko Kodama, Wolfgang Koenig, Michel Krempf, Soo Lim, Alberto J. Lorenzatti, Ruth McPherson, Jesus Millan Nuñez-Cortes, Børge G. Nordestgaard, Hisao Ogawa, Chris J. Packard, Jorge Plutzky, Carlos I. Ponte-Negretti, Aruna Pradhan, Kausik K. Ray, Zeljko Reiner, Paul M. Ridker, Massimiliano Ruscica, Shaukat Sadikot, Hitoshi Shimano, Piyamitr Sritara, Jane K. Stock, Ta Chen Su, Andrey V. Susekov, André Tartar, Marja Riitta Taskinen, Alexander Tenenbaum, Lale S. Tokgözoǧlu, Brian Tomlinson, Anne Tybjærg-Hansen, Paul Valensi, Michal Vrablík, Walter Wahli, Gerald F. Watts, Shizuya Yamashita, Koutaro Yokote, Alberto Zambon, Peter Libby The selective peroxisome proliferator-activated receptor alpha modulator (SPPARMα) paradigm: Conceptual framework and therapeutic potential. Cardiovascular Diabetology. Vol.18, No.1 (2019). doi:10.1186/s12933-019-0864-7 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/51595

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Title

The selective peroxisome proliferator-activated receptor alpha modulator (SPPARMα) paradigm: Conceptual framework and therapeutic potential

Author(s)

Jean Charles Fruchart
 Raul D. Santos
 Carlos Aguilar-Salinas
 Masanori Aikawa
 Khalid Al Rasadi
 Pierre Amarenco
 Philip J. Barter
 Richard Ceska
 Alberto Corsini
 Jean Pierre Després
 Patrick Duriez
 Robert H. Eckel
 Marat V. Ezhov
 Michel Farnier
 Henry N. Ginsberg
 Michel P. Hermans
 Shun Ishibashi
 Fredrik Karpe
 Tatsuhiko Kodama
 Wolfgang Koenig
 Michel Krempf
 Soo Lim
 Alberto J. Lorenzatti
 Ruth McPherson
 Jesus Millan Nuñez-Cortes
 Børge G. Nordestgaard
 Hisao Ogawa
 Chris J. Packard
 Jorge Plutzky
 Carlos I. Ponte-Negretti
 Aruna Pradhan
 Kausik K. Ray
 Zeljko Reiner
 Paul M. Ridker
 Massimiliano Ruscica
 Shaukat Sadikot
 Hitoshi Shimano
 Piyamitr Sritara
 Jane K. Stock
 Ta Chen Su
 Andrey V. Susekov
 André Tartar
 Marja Riitta Taskinen
 Alexander Tenenbaum
 Lale S. Tokgözoǧlu
 Brian Tomlinson
 Anne Tybjærg-Hansen
 Paul Valensi
 Michal Vrablík
 Walter Wahli
 Gerald F. Watts
 Shizuya Yamashita
 Koutaro Yokote
 Alberto Zambon
 Peter Libby

Other Contributor(s)

INRA Pays de la Loire
 Hospital y CRS El Pino
 Jichi Medical University
 Seoul National University Bundang Hospital
 Sultan Qaboos University Hospital
 National Medical Research Center of Cardiology, Moscow
 Hospital General Universitario Gregorio Marañon
 Université Laval
 University of Western Australia
 Københavns Universitet
 Centre Hospitalier Universitaire de Dijon
 Università degli Studi di Milano
 Jaslok Hospital and Research Centre
 University of Helsinki Faculty of Medicine
 University of New South Wales (UNSW) Australia
 Universidad Complutense de Madrid
 University of Oxford
 Hôtel Dieu CHU de Nantes
 University of Tokyo
 Osaka University
 Hacettepe Üniversitesi
 Instituto do Coracao do Hospital das Clinicas
 Brigham and Women's Hospital
 Charles University
 Faculty of Medicine, Ramathibodi Hospital, Mahidol University
 Imperial College London
 Amtssygehuset i Gentofte
 University of Tsukuba
 Cliniques Universitaires Saint-Luc
 Chaim Sheba Medical Center Israel
 University of Ottawa Heart Institute
 Vagelos College of Physicians and Surgeons
 Universität Ulm
 University of Colorado Health Sciences Center
 Universite Paris 13
 Instituto Nacional de la Nutrición Salvador Zubiran
 Deutsches Herzzentrum München
 Rigshospitalet
 University of Zagreb School of Medicine
 Universite Paris 7- Denis Diderot
 Nanyang Technological University
 National Taiwan University
 Tel Aviv University, Sackler Faculty of Medicine
 Boston Medical Center
 Hopital G. et R. Laennec CHU de Nantes
 Chinese University of Hong Kong
 Chiba University
 Harvard Medical School
 University of Glasgow
 Escuela de Medicina y Ciencias de la Salud TecSalud
 INRA Occitanie-Toulouse
 Università degli Studi di Padova
 Université Lille 2 Droit et Santé
 Université de Lausanne (UNIL)
 R3i Foundation
 DAMIC Medical Institute/Rusculleda Foundation for Research
 Russian Medical Academy for Postgraduate Education
 National Cerebral and Cardiovascular Center
 CORDOBA
 Rinku General Medical Center

Abstract

© 2019 The Author(s). In the era of precision medicine, treatments that target specific modifiable characteristics of high-risk patients have the potential to lower further the residual risk of atherosclerotic cardiovascular events. Correction of atherogenic dyslipidemia, however, remains a major unmet clinical need. Elevated plasma triglycerides, with or without low levels of high-density lipoprotein cholesterol (HDL-C), offer a key modifiable component of this common dyslipidemia, especially in insulin resistant conditions such as type 2 diabetes mellitus. The development of selective peroxisome proliferator-activated receptor alpha modulators (SPPARMα) offers an approach to address this treatment gap. This Joint Consensus Panel appraised evidence for the first SPPARMα agonist and concluded that this agent represents a novel therapeutic class, distinct from fibrates, based on pharmacological activity, and, importantly, a safe hepatic and renal profile. The ongoing PROMINENT cardiovascular outcomes trial is testing in 10,000 patients with type 2 diabetes mellitus, elevated triglycerides, and low levels of HDL-C whether treatment with this SPPARMα agonist safely reduces residual cardiovascular risk.

Keyword(s)

Medicine

Availability

URI

https://repository.li.mahidol.ac.th/handle/20.500.14594/51595

Collections

Scopus 2019