Publication: Kidney stone proteomics: an update and perspectives
Issued Date
2021-01-01
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ISSN
17448387
14789450
14789450
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2-s2.0-85112663279
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Mahidol University
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SCOPUS
Bibliographic Citation
Expert Review of Proteomics. Vol.18, No.7 (2021), 557-569
Suggested Citation
Paleerath Peerapen, Visith Thongboonkerd Kidney stone proteomics: an update and perspectives. Expert Review of Proteomics. Vol.18, No.7 (2021), 557-569. doi:10.1080/14789450.2021.1962301 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/76347
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Title
Kidney stone proteomics: an update and perspectives
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Abstract
Introduction: Main problems of kidney stone disease are its increasing prevalence and high recurrence rate after calculi removal in almost all areas around the globe. Despite enormous efforts in the past, its pathogenic mechanisms remain unclear and need further elucidations. Proteomics has thus become an essential tool to unravel such sophisticated disease mechanisms at cellular, subcellular, molecular, tissue, and whole organism levels. Areas covered: This review provides abrief overview of kidney stone disease followed by updates on proteomics for investigating urinary stone modulators, matrix proteins, cellular responses to different types/doses of calcium oxalate (CaOx) crystals, sex hormones and other stimuli, crystal–cell interactions, crystal receptors, secretome, and extracellular vesicles (EVs), all of which lead to better understanding of the disease mechanisms. Finally, the future challenges and translation of these obtained data to the clinic are discussed. Expert opinion: Knowledge from urinary proteomics for exploring the important stone modulators (either inhibitors or promoters) will be helpful for early detection of asymptomatic cases for prompt prevention of symptoms, complications, and new stone formation. Moreover, these modulators may serve as the new therapeutic targets in the future for successful treatment and prevention of kidney stone disease by medications or other means of intervention.