Publication: Identification of immunodominant CD4-restricted epitopes co-located with antibody binding sites in individuals vaccinated with ALVAC-HIV and AIDSVAX B/E.
Accepted Date
2014-11-29
Issued Date
2015-02-09
Resource Type
Language
eng
ISSN
1932-6203 (electronic)
Rights
Mahidol University
Rights Holder(s)
PubMed Central
Bibliographic Citation
Ratto-Kim S, de Souza MS, Currier JR, Karasavvas N, Sidney J, Rolland M, et al. Identification of immunodominant CD4-restricted epitopes co-located with antibody binding sites in individuals vaccinated with ALVAC-HIV and AIDSVAX B/E.PLoS One. 2015 Feb 9;10(2):e0115582.
Suggested Citation
Ratto-Kim, Silvia, de Souza, Mark S., Currier, Jeffrey R., Karasavvas, Nicos, Sidney, John, Rolland, Morgane, Valencia-Micolta, Anais, Madnote, Sirinan, Sette, Alessandro, Sorachai Nitayaphan, สรชัย นิตยพันธ, Punnee Pitisuttuthum, พรรณี ปิติสุทธิธรรม, Jaranit Kaewkungwal, จรณิต แก้วกังวาล, Supachai Rerks-Ngarm, ศุภชัย ฤกษงาม, Connell, Robert O, Michael, Nelson, Robb, Merlin L., Marovich, Mary, Kim, Jerome H. Identification of immunodominant CD4-restricted epitopes co-located with antibody binding sites in individuals vaccinated with ALVAC-HIV and AIDSVAX B/E.. Ratto-Kim S, de Souza MS, Currier JR, Karasavvas N, Sidney J, Rolland M, et al. Identification of immunodominant CD4-restricted epitopes co-located with antibody binding sites in individuals vaccinated with ALVAC-HIV and AIDSVAX B/E.PLoS One. 2015 Feb 9;10(2):e0115582.. doi:10.1371/journal.pone.0115582 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/805
Research Projects
Organizational Units
Authors
Journal Issue
Thesis
Title
Identification of immunodominant CD4-restricted epitopes co-located with antibody binding sites in individuals vaccinated with ALVAC-HIV and AIDSVAX B/E.
Author(s)
Ratto-Kim, Silvia
de Souza, Mark S.
Currier, Jeffrey R.
Karasavvas, Nicos
Sidney, John
Rolland, Morgane
Valencia-Micolta, Anais
Madnote, Sirinan
Sette, Alessandro
Sorachai Nitayaphan
สรชัย นิตยพันธ
Punnee Pitisuttuthum
พรรณี ปิติสุทธิธรรม
Jaranit Kaewkungwal
จรณิต แก้วกังวาล
Supachai Rerks-Ngarm
ศุภชัย ฤกษงาม
Connell, Robert O
Michael, Nelson
Robb, Merlin L.
Marovich, Mary
Kim, Jerome H.
de Souza, Mark S.
Currier, Jeffrey R.
Karasavvas, Nicos
Sidney, John
Rolland, Morgane
Valencia-Micolta, Anais
Madnote, Sirinan
Sette, Alessandro
Sorachai Nitayaphan
สรชัย นิตยพันธ
Punnee Pitisuttuthum
พรรณี ปิติสุทธิธรรม
Jaranit Kaewkungwal
จรณิต แก้วกังวาล
Supachai Rerks-Ngarm
ศุภชัย ฤกษงาม
Connell, Robert O
Michael, Nelson
Robb, Merlin L.
Marovich, Mary
Kim, Jerome H.
Corresponding Author(s)
Abstract
We performed fine epitope mapping of the CD4+ responses in the ALVAC-HIV-AIDSVAX
B/E prime-boost regimen in the Thai Phase III trial (RV144). Non-transformed
Env-specific T cell lines established from RV144 vaccinees were used to determine
the fine epitope mapping of the V2 and C1 responses and the HLA class II
restriction. Data showed that there are two CD4+ epitopes contained within the V2
loop: one encompassing the α4β7 integrin binding site (AA179-181) and the other
nested between two previously described genetic sieve signatures (AA169, AA181).
There was no correlation between the frequencies of CD4+ fine epitope responses
and binding antibody.