Publication: A double-blind placebo control trial of dilazep in β-thalassemia/hemoglobin E patients
Issued Date
1997-12-01
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ISSN
01251562
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2-s2.0-0031306251
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Mahidol University
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SCOPUS
Bibliographic Citation
Southeast Asian Journal of Tropical Medicine and Public Health. Vol.28, (1997), 167-171
Suggested Citation
Nisarat Opartkiattikul, Sathien Sukpanichnant, Wanchai Wanachiwanawin, Suthat Fucharoen, Yoshinori Funahara, Akinobu Sumiyoshi, Kiyohiro Imai, Wanida Sangtawesin, Panutsaya Thientadakul A double-blind placebo control trial of dilazep in β-thalassemia/hemoglobin E patients. Southeast Asian Journal of Tropical Medicine and Public Health. Vol.28, (1997), 167-171. Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/18043
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Title
A double-blind placebo control trial of dilazep in β-thalassemia/hemoglobin E patients
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Abstract
Since the obtained results from the pilot study indicated that dilazep which was a membrane stabilizer would be benefit to treatment and prevention of anemia and chronic leg ulcer in β-thalassemia/hemoglobin E (β-thal/HbE) patients, the authors had continued the study in a second phase, ie a double blind placebo control trial. Twenty-seven β-thal/HbE patients were recruited in the study. Eight patients who suffered from chronic leg ulcer were given dilazep. The rest of patients were given dilazep or placebo according to a randomized table. Hence, 16 patients received dilazep and 11 received placebo. When we compared the number of unit of blood transfusion, hemoglobin level, 2-3 DPG and P50 value between the dilazep and placebo groups using unpaired t-test, we found that there were no statistical differences in any of the parameters. However, when we compared the data within the group using paired t-test, there was statistical decrease in blood requirement after treatment in the dilazep group (p<0.05). Concerning with the treatment of chronic leg ulcer. 3 in 8 patients were completely healed within 3 months. 4 in 8 patients were improved and 1 in 8 patients was not improved There were complaints of skin itching and mild epigastric pain in placebo group but the liver function tests, kidney function tests and cardiac enzyme did not significantly change during the medication.