Publication: Osteocalcin and bone-specific alkaline phosphatase in Asian elephants (Elephas maximus) at different ages
Issued Date
2015-01-01
Resource Type
ISSN
15322971
10900233
10900233
Other identifier(s)
2-s2.0-84946488110
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Mahidol University
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SCOPUS
Bibliographic Citation
Veterinary Journal. Vol.206, No.2 (2015), 239-240
Suggested Citation
Nlin Arya, Walasinee Moonarmart, Nareerat Cheewamongkolnimit, Nutcha Keratikul, Sawinee Poon-iam, Andrew Routh, Pitikarn Bumpenpol, Taweepoke Angkawanish Osteocalcin and bone-specific alkaline phosphatase in Asian elephants (Elephas maximus) at different ages. Veterinary Journal. Vol.206, No.2 (2015), 239-240. doi:10.1016/j.tvjl.2015.07.026 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/35270
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Title
Osteocalcin and bone-specific alkaline phosphatase in Asian elephants (Elephas maximus) at different ages
Abstract
© 2015 Elsevier Ltd. Bone turnover markers could offer a potential alternative means for the early diagnosis of metabolic bone disease in young growing elephants although the baseline of bone turnover markers in elephant is not well established. The aim of this study was to determine any relationship between the age of captive Asian elephants (Elephas maximus) and markers of bone formation.Serum samples from 24 female Asian elephants were collected to evaluate levels of two bone formation markers, namely, osteocalcin (OC) and bone-specific alkaline phosphatase (BAP). Both intact and N-terminal midfragment OC and BAP were negatively correlated with age. The findings demonstrate that younger elephants have a higher rate of bone turnover than older elephants. Use of these and additional bone markers could lead to the establishment of validated protocols for the monitoring of bone disease in elephants.