Publication:
A general direct arylation of polyfluoroarenes with heteroaryl and aryl chlorides catalyzed by palladium indolylphosphine complexes

Issued Date

2015-01-01

Resource Type

Article

ISSN

1861471X
18614728

DOI

10.1002/asia.201500048

Other identifier(s)

2-s2.0-84925384804

Rights

Mahidol University

Rights Holder(s)

SCOPUS

Bibliographic Citation

Chemistry - An Asian Journal. Vol.10, No.4 (2015), 857-861

Suggested Citation

On Ying Yuen, Mueangkaew Charoensak, Chau Ming So, Chutima Kuhakarn, Fuk Yee Kwong A general direct arylation of polyfluoroarenes with heteroaryl and aryl chlorides catalyzed by palladium indolylphosphine complexes. Chemistry - An Asian Journal. Vol.10, No.4 (2015), 857-861. doi:10.1002/asia.201500048 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/35774

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Title

A general direct arylation of polyfluoroarenes with heteroaryl and aryl chlorides catalyzed by palladium indolylphosphine complexes

Author(s)

On Ying Yuen
 Mueangkaew Charoensak
 Chau Ming So
 Chutima Kuhakarn
 Fuk Yee Kwong

Other Contributor(s)

Hong Kong Polytechnic University
 Mahidol University

Abstract

© 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim. The first general examples of direct coupling of heteroaryl chlorides, especially substituted 2-pyridyl chlorides which were previously found to be problematic, with electron-deficient polyfluoroarenes are reported. Pd(OAc)2associated with 3-(dicyclohexylphosphino)-2-phenylindole L1 serves as the effective catalyst which allows the challenging direct coupling of heteroaryl chlorides and polyfluoroarenes. In addition to heterocycles, a wide range of non-activated and activated aryl chlorides and alkenyl chlorides were also applicable under this catalyst system. A catalyst loading down to 1 mol% Pd can be achieved.

Keyword(s)

Chemistry

Availability

URI

https://repository.li.mahidol.ac.th/handle/20.500.14594/35774

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Scopus 2011-2015