Publication: Plaque reduction neutralization antibody test does not accurately predict protection against dengue infection in Ratchaburi cohort, Thailand
Issued Date
2014-03-12
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ISSN
1743422X
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2-s2.0-84898422509
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Mahidol University
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SCOPUS
Bibliographic Citation
Virology Journal. Vol.11, No.1 (2014)
Suggested Citation
Chukiat Sirivichayakul, Arunee Sabchareon, Kriengsak Limkittikul, Sutee Yoksan Plaque reduction neutralization antibody test does not accurately predict protection against dengue infection in Ratchaburi cohort, Thailand. Virology Journal. Vol.11, No.1 (2014). doi:10.1186/1743-422X-11-48 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/33983
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Title
Plaque reduction neutralization antibody test does not accurately predict protection against dengue infection in Ratchaburi cohort, Thailand
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Abstract
Background: The plaque reduction neutralization test (PRNT) is currently the best and most widely accepted approach to measuring virus-neutralizing and protective antibodies to dengue virus, and in assessing the immunogenicity of a dengue vaccine. However, the correlation between presence of dengue-neutralizing antibody and protection from infection is not absolute. Findings. In a cohort study in Ratchaburi Province, Thailand, 48 subjects with serologically confirmed symptomatic dengue infection were tested for pre-existing dengue neutralizing antibody using PRNT. Nine subjects had quite high pre-existing PRNT50 titers (titer >90) to subsequent infecting dengue serotypes, but still had symptomatic infections. Conclusion: This report provides evidence that PRNT may not be a good test for predicting protection against subsequent dengue infection. © 2014Sirivichayakul et al.; licensee BioMed Central Ltd.