Publication: Bis-spiro-azaphilones and azaphilones from the fungi Chaetomium cochliodes VTh01 and C. cochliodes CTh05
| dc.contributor.author | Nutchanat Phonkerd | en_US |
| dc.contributor.author | Somdej Kanokmedhakul | en_US |
| dc.contributor.author | Kwanjai Kanokmedhakul | en_US |
| dc.contributor.author | Kasem Soytong | en_US |
| dc.contributor.author | Samran Prabpai | en_US |
| dc.contributor.author | Palangpon Kongsearee | en_US |
| dc.contributor.other | Khon Kaen University | en_US |
| dc.contributor.other | King Mongkut's Institute of Technology Ladkrabang | en_US |
| dc.contributor.other | Mahidol University | en_US |
| dc.date.accessioned | 2018-07-12T02:17:11Z | |
| dc.date.available | 2018-07-12T02:17:11Z | |
| dc.date.issued | 2008-09-29 | en_US |
| dc.description.abstract | Four new dimeric spiro-azaplilones, cochliodones A-D (1-4), two new azaphliones, chaetoviridines E and F (5 and 6), a new epi-chaetoviridin A (7), together with five known compounds, chaetoviridin A (8), ergosterol (9), chaetochalasin A (10), 24(R)-5α,8α-epidioxyergosta-6-22-diene-3β-ol (11), and ergosterol-β-d-glucoside (12) were isolated from the fungi Chaetomium cochliodes VTh01 and C. cochliodes CTh05. Structures and stereochemistry of the atropisomers 1-3 were determined by single-crystal X-ray diffraction analysis. Compounds 5, 10, and 11 exhibited antimalarial activity against Plasmodium falciparum, while 3, 5, 6, 10, and 11 showed antimycobacterial activity against Mycobacterium tuberculosis. In addition, 5 and 6 also showed cytotoxicity against the KB, BC1, and NCI-H187 cell lines. © 2008 Elsevier Ltd. All rights reserved. | en_US |
| dc.identifier.citation | Tetrahedron. Vol.64, No.40 (2008), 9636-9645 | en_US |
| dc.identifier.doi | 10.1016/j.tet.2008.07.040 | en_US |
| dc.identifier.issn | 00404020 | en_US |
| dc.identifier.other | 2-s2.0-49549092692 | en_US |
| dc.identifier.uri | https://repository.li.mahidol.ac.th/handle/20.500.14594/18855 | |
| dc.rights | Mahidol University | en_US |
| dc.rights.holder | SCOPUS | en_US |
| dc.source.uri | https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=49549092692&origin=inward | en_US |
| dc.subject | Biochemistry, Genetics and Molecular Biology | en_US |
| dc.subject | Chemistry | en_US |
| dc.subject | Pharmacology, Toxicology and Pharmaceutics | en_US |
| dc.title | Bis-spiro-azaphilones and azaphilones from the fungi Chaetomium cochliodes VTh01 and C. cochliodes CTh05 | en_US |
| dc.type | Article | en_US |
| dspace.entity.type | Publication | |
| mu.datasource.scopus | https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=49549092692&origin=inward | en_US |