Publication: The Deformability of Red Blood Cells Parasitized by Plasmodium falciparum and P. vivax
Issued Date
2004-01-15
Resource Type
ISSN
00221899
DOI
Other identifier(s)
2-s2.0-0742324945
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Mahidol University
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SCOPUS
Bibliographic Citation
Journal of Infectious Diseases. Vol.189, No.2 (2004), 190-194
Suggested Citation
Rossarin Suwanarusk, Brian M. Cooke, Arjen M. Dondorp, Kamolrat Silamut, Jetsumon Sattabongkot, Nicholas J. White, Rachanee Udomsangpetch The Deformability of Red Blood Cells Parasitized by Plasmodium falciparum and P. vivax. Journal of Infectious Diseases. Vol.189, No.2 (2004), 190-194. doi:10.1086/380468 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/21409
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Title
The Deformability of Red Blood Cells Parasitized by Plasmodium falciparum and P. vivax
Abstract
Red blood cells (RBCs) must deform considerably during their multiple passages through the microvasculature and the sinusoids of the spleen. RBCs infected with Plasmodium falciparum (Pf-IRBCs) become increasingly rigid as they mature but avoid splenic clearance by sequestering in venules and capillaries. In contrast, RBCs infected with P. vivax (Pv-IRBCs) do not sequester. We compared the effects of P. vivax and P. falciparum infection on RBC deformability in a laminar shear flow system. Pf-IRBCs became more rigid as the parasite matured, but equivalent maturation of Pv-IRBCs resulted in a doubling of flexibility. Coincidentally, the IRBC surface area increased from 56.7 ± 1.3 μm2to 74.7 ± 0.6 μm2to 90.9 ±1.1 μm2in ring-, trophozoite-, and schizont-stage Pv-IRBCs, respectively, whereas Pf-IRBCs did not increase in size. P. vivax increases the deformability of IRBCs and thereby avoids splenic entrapment.