Publication: Immune response in diarrheal patients and asymptomatic carrier with CS6-producing enterotoxigenic Escherichia coli infection
Issued Date
2012-11-01
Resource Type
ISSN
01251562
Other identifier(s)
2-s2.0-84873042167
Rights
Mahidol University
Rights Holder(s)
SCOPUS
Bibliographic Citation
Southeast Asian Journal of Tropical Medicine and Public Health. Vol.43, No.6 (2012), 1452-1460
Suggested Citation
Orapim Puiprom, Siriporn Chantaroj, Shigeaki Matsuda, Pathom Sawanpanyalert, Takeshi Honda, Tetsuya Iida, Tooru Taniguchi Immune response in diarrheal patients and asymptomatic carrier with CS6-producing enterotoxigenic Escherichia coli infection. Southeast Asian Journal of Tropical Medicine and Public Health. Vol.43, No.6 (2012), 1452-1460. Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/14576
Research Projects
Organizational Units
Authors
Journal Issue
Thesis
Title
Immune response in diarrheal patients and asymptomatic carrier with CS6-producing enterotoxigenic Escherichia coli infection
Abstract
Enterotoxigenic Escherichia coli (ETEC) is one of the major causes of diarrhea in children and travelers in developing countries. ETEC colonization factors (CFs) are virulence determinants considered as protective antigens and major targets for vaccine development against ETEC infections. One of the most prevalent CFs, coli surface antigen 6(CS6), a non-fimbrial polymeric protein consisting of two major subunits, CssA and CssB, is produced by approximately 25-35% of ETEC worldwide. We could isolate only CS6-producing ETEC strains from two diarrheal patients and one asymptomatic carrier, but we could not detect CssA- or CssB-specific antibodies in the feces and blood of two patients convalescing from natural ETEC infection and of an asymptomatic carrier using western blotting. Therefore, in order to protect against infection with CS6-producing ETEC, protective levels of CS6 immunity should be incorporated in any future vaccines against ETEC.
