Publication: Suppression by Curcuma comosa Roxb. of pro-inflammatory cytokine secretion in phorbol-12-myristate-13-acetate stimulated human mononuclear cells
Issued Date
2007-04-01
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ISSN
15675769
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2-s2.0-33847071264
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Mahidol University
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SCOPUS
Bibliographic Citation
International Immunopharmacology. Vol.7, No.4 (2007), 524-531
Suggested Citation
Amorntus Sodsai, Pawinee Piyachaturawat, Samaisukh Sophasan, Apichart Suksamrarn, Molvibha Vongsakul Suppression by Curcuma comosa Roxb. of pro-inflammatory cytokine secretion in phorbol-12-myristate-13-acetate stimulated human mononuclear cells. International Immunopharmacology. Vol.7, No.4 (2007), 524-531. doi:10.1016/j.intimp.2006.12.013 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/24564
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Title
Suppression by Curcuma comosa Roxb. of pro-inflammatory cytokine secretion in phorbol-12-myristate-13-acetate stimulated human mononuclear cells
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Abstract
Curcuma comosa Roxb. is a medicinal plant that has traditionally been used in Thailand for treatment of inflammation in postpartum uterine bleeding. The purpose of this study was to evaluate its anti-inflammatory effects using peripheral blood mononuclear cells (PBMC) and human pro-monocytic cell line (U937). Pretreatment with hexane or ethanol extract or two diarylhepatanoids (5-hydroxy-7-(4-hydroxyphenyl)-1-phenyl-(1E)-1-heptene and 7-(3,4-dihydroxyphenyl)-5-hydroxy-1-phenyl-(1E)-1-heptene) of C. comosa significantly decreased the release of pro-inflammatory cytokines, tumor necrosis factor α (TNF-α) and interleukin-1β, from phorbol-12-myristate-13-acetate (PMA)-stimulated PBMC and U937 cells. In PMA-stimulated U937 cells, the two C. comosa diarylhepatanoids reduced the expression of TNF-α and suppressed expression of IκB kinase and activation of nuclear factor kappa B. These results indicated that C. comosa and its diarylheptanoids have anti-inflammatory properties which could be exploited for clinical use. © 2007 Elsevier B.V. All rights reserved.