Publication: Immunogenicity of a Japanese encephalitis chimeric virus vaccine as a booster dose after primary vaccination with SA14-14-2 vaccine in Thai children
Issued Date
2016-10-17
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ISSN
18732518
0264410X
0264410X
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2-s2.0-84989167977
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Mahidol University
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SCOPUS
Bibliographic Citation
Vaccine. Vol.34, No.44 (2016), 5279-5283
Suggested Citation
Pakpoom Janewongwirot, Thanyawee Puthanakit, Suvaporn Anugulruengkitt, Watsamon Jantarabenjakul, Chayapa Phasomsap, Sompong Chumket, Sutee Yoksan, Chitsanu Pancharoen Immunogenicity of a Japanese encephalitis chimeric virus vaccine as a booster dose after primary vaccination with SA14-14-2 vaccine in Thai children. Vaccine. Vol.34, No.44 (2016), 5279-5283. doi:10.1016/j.vaccine.2016.09.005 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/42916
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Title
Immunogenicity of a Japanese encephalitis chimeric virus vaccine as a booster dose after primary vaccination with SA14-14-2 vaccine in Thai children
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Abstract
© 2016 Elsevier Ltd Background Japanese Encephalitis chimeric virus vaccine (JE-CV) and SA14-14-2 vaccine are live-attenuated JE vaccines produced from the same virus strain. Data on interchangeability is limited. Objectives To evaluate the immunogenicity and safety of JE-CV booster after primary vaccination with SA14-14-2 vaccine. Methods This study was an open-label clinical trial in Thai children who had received a primary SA14-14-2 vaccination at 12–24 months before enrollment (ClinicalTrials.gov NCT02602652). JE-CV was administered. A 50% plaque reduction neutralization test (PRNT50) against three virus strains; JE-CV, SA-14-14-2 and wild-type JE virus was measured before and 28-days post vaccination. The laboratory was performed at PRNT50titers ⩾10 (1/dil) were considered seroprotective against JE. Geometric mean titer (GMT) of PRNT50was calculated. Adverse events were observed for 28 days. Results From March 2014 to June 2015, 50 children (64% male) were enrolled. Mean age and duration after primary vaccination was 26.9 (SD 4.6) and 12.8 (SD 2.7) months, respectively. The proportion of participants who had PRNT50pre and post-booster vaccination were 92% and 96% against JE-CV virus, 56% and 98% against SA-14-14-2 strain and 70% and 98% against wild-type JE virus, respectively. Solicited injection site reactions including erythema, pain and swelling occurred in 18%, 10% and 4% of subjects, respectively. Four children (8%) had fever (⩾37.7 Celsius). Eight children (16%) had adverse events, which were not related to the vaccine. Conclusions AJE-CV booster dose is highly immunogenic and safe among children who previously received SA14-14-2 vaccine.