Publication: Anti-HIV 1 activity of xanthones from the bark of mammea harmandii
Issued Date
2018-01-01
Resource Type
ISSN
15559475
1934578X
1934578X
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2-s2.0-85048515502
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Mahidol University
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SCOPUS
Bibliographic Citation
Natural Product Communications. Vol.13, No.1 (2018), 53-56
Suggested Citation
Ponsiri Liangsakul, Chutima Kuhakarn, Sakchai Hongthong, Surawat Jariyawat, Kanoknetr Suksen, Radeekorn Akkarawongsapat, Jitra Limthongkul, Chanita Napaswad, Vichai Reutrakul Anti-HIV 1 activity of xanthones from the bark of mammea harmandii. Natural Product Communications. Vol.13, No.1 (2018), 53-56. Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/44865
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Title
Anti-HIV 1 activity of xanthones from the bark of mammea harmandii
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Abstract
© 2018 Natural Product Incorporation. All Rights Reserved. A new xanthone glycoside 1 together with four known flavonoid derivatives, astilbin (2), neoastilbin (3), isoastilbin (4), and epicatechin (5) were isolated from the ethyl acetate fraction partitioned from the methanol extract of the bark of Mammea harmandii. The chemical structures of all isolated compounds were established on the basis of their spectroscopic data. Compound 1 exhibited selective significant inhibitory activity in the anti-syncytium assay with an EC50 value of 11.44 M (SI = 14.03) while it was found inactive against HIV 1 reverse transcriptase as well as cytotoxic activity.