Publication:
Age-dependent differences in pulmonary host responses in ARDS: a prospective observational cohort study

Issued Date

2019-12-01

Resource Type

Article

ISSN

21105820

DOI

10.1186/s13613-019-0529-4

Other identifier(s)

2-s2.0-85065813716

Rights

Mahidol University

Rights Holder(s)

SCOPUS

Bibliographic Citation

Annals of Intensive Care. Vol.9, No.1 (2019)

Suggested Citation

Laura R. Schouten, Anton H. van Kaam, Franziska Kohse, Floor Veltkamp, Lieuwe D. Bos, Friso M. de Beer, Roosmarijn T. van Hooijdonk, Janneke Horn, Marleen Straat, Esther Witteveen, Gerie J. Glas, Luuk Wieske, Lonneke A. van Vught, Maryse A. Wiewel, Sarah A. Ingelse, Bart Cortjens, Job B. van Woensel, Albert P. Bos, Thomas Walther, Marcus J. Schultz, Roelie M. Wösten-van Asperen, Friso M. de Beer, Janneke Horn, Arie J. Hoogendijk, Mischa A. Huson, Tom van der Poll, Brendon Scicluna, Marcus J. Schultz, Maryse A. Wiewel, Marc J. Bonten, Olaf L. Cremer, Jos F. Frencken, Kirsten van de Groep, Peter M. Klein Klouwenberg, Maria E. Koster-Brouwer, David S. Ong, Diana M. Verboom Age-dependent differences in pulmonary host responses in ARDS: a prospective observational cohort study. Annals of Intensive Care. Vol.9, No.1 (2019). doi:10.1186/s13613-019-0529-4 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/51281

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Title

Age-dependent differences in pulmonary host responses in ARDS: a prospective observational cohort study

Author(s)

Laura R. Schouten
 Anton H. van Kaam
 Franziska Kohse
 Floor Veltkamp
 Lieuwe D. Bos
 Friso M. de Beer
 Roosmarijn T. van Hooijdonk
 Janneke Horn
 Marleen Straat
 Esther Witteveen
 Gerie J. Glas
 Luuk Wieske
 Lonneke A. van Vught
 Maryse A. Wiewel
 Sarah A. Ingelse
 Bart Cortjens
 Job B. van Woensel
 Albert P. Bos
 Thomas Walther
 Marcus J. Schultz
 Roelie M. Wösten-van Asperen
 Friso M. de Beer
 Janneke Horn
 Arie J. Hoogendijk
 Mischa A. Huson
 Tom van der Poll
 Brendon Scicluna
 Marcus J. Schultz
 Maryse A. Wiewel
 Marc J. Bonten
 Olaf L. Cremer
 Jos F. Frencken
 Kirsten van de Groep
 Peter M. Klein Klouwenberg
 Maria E. Koster-Brouwer
 David S. Ong
 Diana M. Verboom

Other Contributor(s)

Wilhelmina Children's Hospital
 University College Cork
 Mahidol University
 Amsterdam UMC - University of Amsterdam
 University Medicine Greifswald

Abstract

© 2019, The Author(s). Background: Results from preclinical studies suggest that age-dependent differences in host defense and the pulmonary renin–angiotensin system (RAS) are responsible for observed differences in epidemiology of acute respiratory distress syndrome (ARDS) between children and adults. The present study compares biomarkers of host defense and RAS in bronchoalveolar lavage (BAL) fluid from neonates, children, adults, and older adults with ARDS. Methods: In this prospective observational study, we enrolled mechanical ventilated ARDS patients categorized into four age groups: 20 neonates (< 28 days corrected postnatal age), 29 children (28 days–18 years), 26 adults (18–65 years), and 17 older adults (> 65 years of age). All patients underwent a nondirected BAL within 72 h after intubation. Activities of the two main enzymes of RAS, angiotensin converting enzyme (ACE) and ACE2, and levels of biomarkers of inflammation, endothelial activation, and epithelial damage were determined in BAL fluid. Results: Levels of myeloperoxidase, interleukin (IL)-6, IL-10, and p-selectin were higher with increasing age, whereas intercellular adhesion molecule-1 was higher in neonates. No differences in activity of ACE and ACE2 were seen between the four age groups. Conclusions: Age-dependent differences in the levels of biomarkers in lungs of ARDS patients are present. Especially, higher levels of markers involved in the neutrophil response were found with increasing age. In contrast to preclinical studies, age is not associated with changes in the pulmonary RAS.

Keyword(s)

Medicine

Availability

URI

https://repository.li.mahidol.ac.th/handle/20.500.14594/51281

Collections

Scopus 2019