Publication: Health promoting benefits of pongamol: An overview
Issued Date
2021-10-01
Resource Type
ISSN
19506007
07533322
07533322
Other identifier(s)
2-s2.0-85113739660
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Mahidol University
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SCOPUS
Bibliographic Citation
Biomedicine and Pharmacotherapy. Vol.142, (2021)
Suggested Citation
Shamima Jahan, Md Hasan Mahmud, Zidan Khan, Ashraful Alam, Anees Ahmed Khalil, Abdur Rauf, Abu Montakim Tareq, Firzan Nainu, Syed Mohammed Tareq, Talha Bin Emran, Muneeb Khan, Ishaq N. Khan, Polrat Wilairatana, Mohammad S. Mubarak Health promoting benefits of pongamol: An overview. Biomedicine and Pharmacotherapy. Vol.142, (2021). doi:10.1016/j.biopha.2021.112109 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/78943
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Title
Health promoting benefits of pongamol: An overview
Abstract
Plant-derived chemicals are a source of novel chemotherapeutic agents. Throughout the human civilization, these novel chemicals have led to the discovery of new pharmacological active agents. Research on herbal medicine is of great importance, as most of the active agents used for treating numerous diseases are from natural sources, while other agents are either semisynthetic or synthetic. Pongamol, a flavonoid, which is the main constituent of Pongamia pinnata, is one such active agents, which exhibits diverse pharmacological activities. Various in vivo and in vitro studies revealed that pongamol is a potentially active agent, as it exerts anticancer, anti-inflammatory, antioxidant, antimicrobial, and anti-diabetic activities. Accordingly, the aim of the present review was to give an up-to-date overview on the chemistry, isolation, bioavailability, pharmacological activity, and health benefits of pongamol. This review focuses on the medicinal and health promoting activities of pongamol, along with possible mechanisms of action. For this purpose, this review summarizes the most recent literature pertaining to pongamol as a therapeutic agent against several diseases. In addition, the review covers information related to the toxicological assessment and safety of this phytochemical, and highlights the medicinal and folk values of this compound against various diseases and ailments.