Publication: Global validation of the WSES Sepsis Severity Score for patients with complicated intra-abdominal infections: A prospective multicentre study (WISS Study)
Issued Date
2015-12-16
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ISSN
17497922
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2-s2.0-84949808332
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Mahidol University
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SCOPUS
Bibliographic Citation
World Journal of Emergency Surgery. Vol.10, No.1 (2015)
Suggested Citation
Massimo Sartelli, Fikri M. Abu-Zidan, Fausto Catena, Ewen A. Griffiths, Salomone Di Saverio, Raul Coimbra, Carlos A. Ordoñez, Ari Leppaniemi, Gustavo P. Fraga, Federico Coccolini, Ferdinando Agresta, Asrhaf Abbas, Saleh Abdel Kader, John Agboola, Adamu Amhed, Adesina Ajibade, Seckin Akkucuk, Bandar Alharthi, Dimitrios Anyfantakis, Goran Augustin, Gianluca Baiocchi, Miklosh Bala, Oussama Baraket, Savas Bayrak, Giovanni Bellanova, Marcelo A. Beltràn, Roberto Bini, Matthew Boal, Andrey V. Borodach, Konstantinos Bouliaris, Frederic Branger, Daniele Brunelli, Marco Catani, Asri Che Jusoh, Alain Chichom-Mefire, Gianfranco Cocorullo, Elif Colak, David Costa, Silvia Costa, Yunfeng Cui, Geanina Loredana Curca, Terry Curry, Koray Das, Samir Delibegovic, Zaza Demetrashvili, Isidoro Di Carlo, Nadezda Drozdova, Tamer El Zalabany, Mushira Abdulaziz Enani, Mario Faro, Mahir Gachabayov, Teresa Giménez Maurel, Georgios Gkiokas, Carlos Augusto Gomes, Ricardo Alessandro Teixeira Gonsaga, Gianluca Guercioni, Ali Guner, Sanjay Gupta, Sandra Gutierrez, Martin Hutan, Orestis Ioannidis, Arda Isik, Yoshimitsu Izawa, Sumita A. Jain, Mantas Jokubauskas, Aleksandar Karamarkovic, Saila Kauhanen, Robin Kaushik, Jakub Kenig, Vladimir Khokha, Jae Il Kim, Victor Kong, Renol Koshy, Avidyl Krasniqi, Ashok Kshirsagar, Zygimantas Kuliesius, Konstantinos Lasithiotakis, Pedro Leão, Jae Gil Lee, Miguel Leon, Aintzane Lizarazu Pérez, Varut Lohsiriwat, Eudaldo López-Tomassetti Fernandez, Eftychios Lostoridis, Raghuveer Mn, Piotr Major, Athanasios Marinis, Daniele Marrelli, Aleix Martinez-Perez, Sanjay Marwah, Michael McFarlane, Renato Bessa Melo, Cristian Mesina, Nick Michalopoulos, Radu Moldovanu, Ouadii Mouaqit, Akutu Munyika, Ionut Negoi, Ioannis Nikolopoulos, Gabriela Elisa Nita Global validation of the WSES Sepsis Severity Score for patients with complicated intra-abdominal infections: A prospective multicentre study (WISS Study). World Journal of Emergency Surgery. Vol.10, No.1 (2015). doi:10.1186/s13017-015-0055-0 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/36210
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Title
Global validation of the WSES Sepsis Severity Score for patients with complicated intra-abdominal infections: A prospective multicentre study (WISS Study)
Author(s)
Massimo Sartelli
Fikri M. Abu-Zidan
Fausto Catena
Ewen A. Griffiths
Salomone Di Saverio
Raul Coimbra
Carlos A. Ordoñez
Ari Leppaniemi
Gustavo P. Fraga
Federico Coccolini
Ferdinando Agresta
Asrhaf Abbas
Saleh Abdel Kader
John Agboola
Adamu Amhed
Adesina Ajibade
Seckin Akkucuk
Bandar Alharthi
Dimitrios Anyfantakis
Goran Augustin
Gianluca Baiocchi
Miklosh Bala
Oussama Baraket
Savas Bayrak
Giovanni Bellanova
Marcelo A. Beltràn
Roberto Bini
Matthew Boal
Andrey V. Borodach
Konstantinos Bouliaris
Frederic Branger
Daniele Brunelli
Marco Catani
Asri Che Jusoh
Alain Chichom-Mefire
Gianfranco Cocorullo
Elif Colak
David Costa
Silvia Costa
Yunfeng Cui
Geanina Loredana Curca
Terry Curry
Koray Das
Samir Delibegovic
Zaza Demetrashvili
Isidoro Di Carlo
Nadezda Drozdova
Tamer El Zalabany
Mushira Abdulaziz Enani
Mario Faro
Mahir Gachabayov
Teresa Giménez Maurel
Georgios Gkiokas
Carlos Augusto Gomes
Ricardo Alessandro Teixeira Gonsaga
Gianluca Guercioni
Ali Guner
Sanjay Gupta
Sandra Gutierrez
Martin Hutan
Orestis Ioannidis
Arda Isik
Yoshimitsu Izawa
Sumita A. Jain
Mantas Jokubauskas
Aleksandar Karamarkovic
Saila Kauhanen
Robin Kaushik
Jakub Kenig
Vladimir Khokha
Jae Il Kim
Victor Kong
Renol Koshy
Avidyl Krasniqi
Ashok Kshirsagar
Zygimantas Kuliesius
Konstantinos Lasithiotakis
Pedro Leão
Jae Gil Lee
Miguel Leon
Aintzane Lizarazu Pérez
Varut Lohsiriwat
Eudaldo López-Tomassetti Fernandez
Eftychios Lostoridis
Raghuveer Mn
Piotr Major
Athanasios Marinis
Daniele Marrelli
Aleix Martinez-Perez
Sanjay Marwah
Michael McFarlane
Renato Bessa Melo
Cristian Mesina
Nick Michalopoulos
Radu Moldovanu
Ouadii Mouaqit
Akutu Munyika
Ionut Negoi
Ioannis Nikolopoulos
Gabriela Elisa Nita
Fikri M. Abu-Zidan
Fausto Catena
Ewen A. Griffiths
Salomone Di Saverio
Raul Coimbra
Carlos A. Ordoñez
Ari Leppaniemi
Gustavo P. Fraga
Federico Coccolini
Ferdinando Agresta
Asrhaf Abbas
Saleh Abdel Kader
John Agboola
Adamu Amhed
Adesina Ajibade
Seckin Akkucuk
Bandar Alharthi
Dimitrios Anyfantakis
Goran Augustin
Gianluca Baiocchi
Miklosh Bala
Oussama Baraket
Savas Bayrak
Giovanni Bellanova
Marcelo A. Beltràn
Roberto Bini
Matthew Boal
Andrey V. Borodach
Konstantinos Bouliaris
Frederic Branger
Daniele Brunelli
Marco Catani
Asri Che Jusoh
Alain Chichom-Mefire
Gianfranco Cocorullo
Elif Colak
David Costa
Silvia Costa
Yunfeng Cui
Geanina Loredana Curca
Terry Curry
Koray Das
Samir Delibegovic
Zaza Demetrashvili
Isidoro Di Carlo
Nadezda Drozdova
Tamer El Zalabany
Mushira Abdulaziz Enani
Mario Faro
Mahir Gachabayov
Teresa Giménez Maurel
Georgios Gkiokas
Carlos Augusto Gomes
Ricardo Alessandro Teixeira Gonsaga
Gianluca Guercioni
Ali Guner
Sanjay Gupta
Sandra Gutierrez
Martin Hutan
Orestis Ioannidis
Arda Isik
Yoshimitsu Izawa
Sumita A. Jain
Mantas Jokubauskas
Aleksandar Karamarkovic
Saila Kauhanen
Robin Kaushik
Jakub Kenig
Vladimir Khokha
Jae Il Kim
Victor Kong
Renol Koshy
Avidyl Krasniqi
Ashok Kshirsagar
Zygimantas Kuliesius
Konstantinos Lasithiotakis
Pedro Leão
Jae Gil Lee
Miguel Leon
Aintzane Lizarazu Pérez
Varut Lohsiriwat
Eudaldo López-Tomassetti Fernandez
Eftychios Lostoridis
Raghuveer Mn
Piotr Major
Athanasios Marinis
Daniele Marrelli
Aleix Martinez-Perez
Sanjay Marwah
Michael McFarlane
Renato Bessa Melo
Cristian Mesina
Nick Michalopoulos
Radu Moldovanu
Ouadii Mouaqit
Akutu Munyika
Ionut Negoi
Ioannis Nikolopoulos
Gabriela Elisa Nita
Other Contributor(s)
Macerata Hospital
College of Medicine and Health Sciences United Arab Emirates University
Maggiore Hospital
Queen Elizabeth Hospital, University Hospital Birmingham NHS Foundation Trust
Ospedale Maggiore
University of California, San Diego
Universidad del Valle, Cali
Helsinki University Hospital
Universidade Estadual de Campinas
Papa Giovanni XXIII Hospital
General Surgery
Mansoura University, Faculty of Medicine
Al Ain Hospital
University of Ilorin
Ahmadu Bello University
LAUTECH Teaching Hospital
Mustafa Kemal Universitesi
King Fahad Medical City
Primary Health Care Centre of Kissamos
University of Zagreb School of Medicine
Brescia Civil Hospital
Hadassah University Medical Centre
Regional Hospital of Bizerte
T. C. Saglik Bakanligi, Taksim Egitim ve Arastirma Hastanesi
Ospedale S. Chiara
Hospital de La Serena
SG Bosco Hospital
Novosibirsk State Medical University
University Hospital of Larissa
CHU Angers
Ospedale di Città di Castello
Universita degli Studi di Roma La Sapienza
Kuala Krai Hospital
Regional Hospital
Policlinico Paolo Giaccone
Samsun Education and Research Hospital
Universitat d'Alacant
CHVNG/E
Tianjin Nankai Hospital
Emergency Municipal Hospital Pascani
Adana Numune Training and Research Hospital
University Clinical Center
Kipshidze Central University Hospital
Hamad General Hospital
Pauls Stradins Clinical University Hospital
Bahrain Defence Force Royal Medical Services
Fundacao Universitaria do ABC, Faculdade de Medicina do ABC
Vladimir City Clinical Hospital of Emergency Medicine
Hospital Miguel Servet
Aretaieion Hospital
Hospital Universitário Terezinha de Jesus
Hospital Escola Padre Albino
Ascoli Piceno Hospital
Trabzon Kanuni Training and Research Hospital
Government Medical College & Hospital Chandigarh
University Hospital in Bratislava
General Hospital of Kavala
Mengucek Gazi Training and Research Hospital
Jichi Medical University
S. M. S. Hospital
Lithuanian University of Health Sciences
University of Belgrade
Turun Yliopistollinen Keskussairaala
Uniwersytet Jagiellonski w Krakowie
City Hospital
Inje University, College of Medicine
Edendale Hospital
University Clinical Center of Kosovo
Krishna Hospital
Vilniaus universitetas
NHS Foundation Trust
Universidade do Minho, Escola de Ciencias da Saude
Yonsei University College of Medicine
Hospital Universitario La Paz
Hospital Universitario Donostia
Mahidol University
Hospital Insular, Las Palmas
Kavala General Hospital
Mysore Medical College
Collegium Medicum Uniwersytet Jagiellonskiego
Tzanion General Hospital
Le Scotte Hospital
University Hospital
Pandit Bhagwat Dayal Sharma Postgraduate Institute of Medical Sciences
University Hospital of the West Indies
Sao Joao Hospital
Emergency Hospital of Craiova
Aristotle University of Thessaloniki
CH Armentieres
National Institute of Hygiene
Onandjokwe Hospital
Emergency Hospital of Bucharest
National Health Service
College of Medicine and Health Sciences United Arab Emirates University
Maggiore Hospital
Queen Elizabeth Hospital, University Hospital Birmingham NHS Foundation Trust
Ospedale Maggiore
University of California, San Diego
Universidad del Valle, Cali
Helsinki University Hospital
Universidade Estadual de Campinas
Papa Giovanni XXIII Hospital
General Surgery
Mansoura University, Faculty of Medicine
Al Ain Hospital
University of Ilorin
Ahmadu Bello University
LAUTECH Teaching Hospital
Mustafa Kemal Universitesi
King Fahad Medical City
Primary Health Care Centre of Kissamos
University of Zagreb School of Medicine
Brescia Civil Hospital
Hadassah University Medical Centre
Regional Hospital of Bizerte
T. C. Saglik Bakanligi, Taksim Egitim ve Arastirma Hastanesi
Ospedale S. Chiara
Hospital de La Serena
SG Bosco Hospital
Novosibirsk State Medical University
University Hospital of Larissa
CHU Angers
Ospedale di Città di Castello
Universita degli Studi di Roma La Sapienza
Kuala Krai Hospital
Regional Hospital
Policlinico Paolo Giaccone
Samsun Education and Research Hospital
Universitat d'Alacant
CHVNG/E
Tianjin Nankai Hospital
Emergency Municipal Hospital Pascani
Adana Numune Training and Research Hospital
University Clinical Center
Kipshidze Central University Hospital
Hamad General Hospital
Pauls Stradins Clinical University Hospital
Bahrain Defence Force Royal Medical Services
Fundacao Universitaria do ABC, Faculdade de Medicina do ABC
Vladimir City Clinical Hospital of Emergency Medicine
Hospital Miguel Servet
Aretaieion Hospital
Hospital Universitário Terezinha de Jesus
Hospital Escola Padre Albino
Ascoli Piceno Hospital
Trabzon Kanuni Training and Research Hospital
Government Medical College & Hospital Chandigarh
University Hospital in Bratislava
General Hospital of Kavala
Mengucek Gazi Training and Research Hospital
Jichi Medical University
S. M. S. Hospital
Lithuanian University of Health Sciences
University of Belgrade
Turun Yliopistollinen Keskussairaala
Uniwersytet Jagiellonski w Krakowie
City Hospital
Inje University, College of Medicine
Edendale Hospital
University Clinical Center of Kosovo
Krishna Hospital
Vilniaus universitetas
NHS Foundation Trust
Universidade do Minho, Escola de Ciencias da Saude
Yonsei University College of Medicine
Hospital Universitario La Paz
Hospital Universitario Donostia
Mahidol University
Hospital Insular, Las Palmas
Kavala General Hospital
Mysore Medical College
Collegium Medicum Uniwersytet Jagiellonskiego
Tzanion General Hospital
Le Scotte Hospital
University Hospital
Pandit Bhagwat Dayal Sharma Postgraduate Institute of Medical Sciences
University Hospital of the West Indies
Sao Joao Hospital
Emergency Hospital of Craiova
Aristotle University of Thessaloniki
CH Armentieres
National Institute of Hygiene
Onandjokwe Hospital
Emergency Hospital of Bucharest
National Health Service
Abstract
© 2015 Sartelli et al. Background: To validate a new practical Sepsis Severity Score for patients with complicated intra-abdominal infections (cIAIs) including the clinical conditions at the admission (severe sepsis/septic shock), the origin of the cIAIs, the delay in source control, the setting of acquisition and any risk factors such as age and immunosuppression. Methods: The WISS study (WSES cIAIs Score Study) is a multicenter observational study underwent in 132 medical institutions worldwide during a four-month study period (October 2014-February 2015). Four thousand five hundred thirty-three patients with a mean age of 51.2years (range 18-99) were enrolled in the WISS study. Results: Univariate analysis has shown that all factors that were previously included in the WSES Sepsis Severity Score were highly statistically significant between those who died and those who survived (p < 0.0001). The multivariate logistic regression model was highly significant (p < 0.0001, R2 = 0.54) and showed that all these factors were independent in predicting mortality of sepsis. Receiver Operator Curve has shown that the WSES Severity Sepsis Score had an excellent prediction for mortality. A score above 5.5 was the best predictor of mortality having a sensitivity of 89.2%, a specificity of 83.5% and a positive likelihood ratio of 5.4. Conclusions: WSES Sepsis Severity Score for patients with complicated Intra-abdominal infections can be used on global level. It has shown high sensitivity, specificity, and likelihood ratio that may help us in making clinical decisions.