Publication: Report from the killer immunoglobulin-like receptor (KIR) anthropology component of the 15th international histocompatibility workshop: Worldwide variation in the KIR loci and further evidence for the co-evolution of KIR and HLA
Issued Date
2010-07-01
Resource Type
ISSN
13990039
00012815
00012815
Other identifier(s)
2-s2.0-77953303308
Rights
Mahidol University
Rights Holder(s)
SCOPUS
Bibliographic Citation
Tissue Antigens. Vol.76, No.1 (2010), 9-17
Suggested Citation
J. A. Hollenbach, A. Meenagh, C. Sleator, C. Alaez, M. Bengoche, A. Canossi, G. Contreras, L. Creary, I. Evseeva, C. Gorodezky, R. A. Hardie, T. Hemming Karlsen, B. Lie, M. Luo, M. Martinetti, C. Navarette, D. C.M. De Oliveira, G. Ozzella, A. Pasi, E. Pavlova, S. Pinto, L. C. Porto, P. Santos, A. Slavcev, D. Srinak, S. Tavoularis, S. Tonks, E. Trachtenberg, S. Vejbaesya, D. Middleton Report from the killer immunoglobulin-like receptor (KIR) anthropology component of the 15th international histocompatibility workshop: Worldwide variation in the KIR loci and further evidence for the co-evolution of KIR and HLA. Tissue Antigens. Vol.76, No.1 (2010), 9-17. doi:10.1111/j.1399-0039.2010.01459.x Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/28685
Research Projects
Organizational Units
Authors
Journal Issue
Thesis
Title
Report from the killer immunoglobulin-like receptor (KIR) anthropology component of the 15th international histocompatibility workshop: Worldwide variation in the KIR loci and further evidence for the co-evolution of KIR and HLA
Author(s)
J. A. Hollenbach
A. Meenagh
C. Sleator
C. Alaez
M. Bengoche
A. Canossi
G. Contreras
L. Creary
I. Evseeva
C. Gorodezky
R. A. Hardie
T. Hemming Karlsen
B. Lie
M. Luo
M. Martinetti
C. Navarette
D. C.M. De Oliveira
G. Ozzella
A. Pasi
E. Pavlova
S. Pinto
L. C. Porto
P. Santos
A. Slavcev
D. Srinak
S. Tavoularis
S. Tonks
E. Trachtenberg
S. Vejbaesya
D. Middleton
A. Meenagh
C. Sleator
C. Alaez
M. Bengoche
A. Canossi
G. Contreras
L. Creary
I. Evseeva
C. Gorodezky
R. A. Hardie
T. Hemming Karlsen
B. Lie
M. Luo
M. Martinetti
C. Navarette
D. C.M. De Oliveira
G. Ozzella
A. Pasi
E. Pavlova
S. Pinto
L. C. Porto
P. Santos
A. Slavcev
D. Srinak
S. Tavoularis
S. Tonks
E. Trachtenberg
S. Vejbaesya
D. Middleton
Other Contributor(s)
UCSF Benioff Children's Hospital Oakland
Northern Ireland Histocompatibility
Instituto Nacional de Diagnostico y Referencia Epidemiologicos
Instituto Nacional de Donación y Trasplante (INDT
Consiglio Nazionale delle Ricerche
NHSBT
University of Oxford
University of Manitoba
Rikshospitalet-Radiumhospitalet HF
Fondazione IRCCS Policlinico San Matteo
Universidade do Estado do Rio de Janeiro
Institutu Klinicke a Experimentalni Mediciny
Centre for Histocompatibility of the Centre
Mahidol University
Canadian Blood Services
Weatherall Institute of Molecular Medicine
University of Liverpool
Northern Ireland Histocompatibility
Instituto Nacional de Diagnostico y Referencia Epidemiologicos
Instituto Nacional de Donación y Trasplante (INDT
Consiglio Nazionale delle Ricerche
NHSBT
University of Oxford
University of Manitoba
Rikshospitalet-Radiumhospitalet HF
Fondazione IRCCS Policlinico San Matteo
Universidade do Estado do Rio de Janeiro
Institutu Klinicke a Experimentalni Mediciny
Centre for Histocompatibility of the Centre
Mahidol University
Canadian Blood Services
Weatherall Institute of Molecular Medicine
University of Liverpool
Abstract
The killer immunoglobulin-like receptor (KIR) anthropology component of the 15th International Histocompatibility Workshop (IHIWS) sought to explore worldwide population variation in the KIR loci, and to examine the relationship between KIR genes and their human leukocyte antigen (HLA) ligands. Fifteen laboratories submitted KIR genotype and HLA ligand data in 27 populations from six broad ethnic groups. Data were analyzed for correlations between the frequencies of KIR and their known HLA ligands. In addition, allelic typing was performed for KIR2DL2 and 3DL1 in a subset of populations. Strong and significant correlations were observed between KIR2DL2, 2DL3 genotype frequencies and the frequency of their ligand, HLA-C1. In contrast, only weak associations were seen for 3DL1, 3DS1 and the HLA-Bw4 ligand. Although some aspects of the correlations observed here differ from those reported in other populations, these data provide additional evidence of linked evolutionary histories for some KIR and HLA loci. Investigation of allele-level variation for the B haplotype locus KIR 2DL2 showed that two alleles, *001 and *003, predominate in all populations in this study. Much more allelic variation was observed for the A haplotype locus 3DL1, with several alleles observed at moderate frequencies and extensive variation observed between populations. © 2010 John Wiley & Sons A/S.