Publication: High Dietary Cholesterol Masks Type 2 Diabetes-Induced
Submitted Date
2014-09-09
Issued Date
2014-09-09
Resource Type
Language
eng
ISSN
0024-4201 (Print)
1558-9307 (Online)
1558-9307 (Online)
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Mahidol University
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Lipids
Bibliographic Citation
Lipids. Vol. 49, No. 10 (2014), 975 – 986
Suggested Citation
Sarawut Lapmanee, Narattaphol Charoenphandhu, Ratchaneevan Aeimlapa, Panan Suntornsaratoon, Kannikar Wongdee, Wacharaporn Tiyasatkulkovit, Kanchana Kengkoom, Khuanjit Chaimongkolnukul, Dutmanee Seriwatanachai, Nateetip Krishnamra High Dietary Cholesterol Masks Type 2 Diabetes-Induced. Lipids. Vol. 49, No. 10 (2014), 975 – 986. doi:10.1007/s11745-014-3950-3 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/22821
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Title
High Dietary Cholesterol Masks Type 2 Diabetes-Induced
Other Contributor(s)
Abstract
Type 2 diabetes mellitus (T2DM) often occurs
concurrently with high blood cholesterol or dyslipidemia.Although T2DM has been hypothesized to impair bone
microstructure, several investigations showed that, when
compared to age-matched healthy individuals, T2DM
patients had normal or relatively high bone mineral density
(BMD). Since cholesterol and lipids profoundly affect
the function of osteoblasts and osteoclasts, it might be
cholesterol that obscured the changes in BMD and bone
microstructure in T2DM. The present study, therefore,
aimed to determine bone elongation, epiphyseal histology,
and bone microstructure in non-obese T2DM Goto-Kakizaki
rats treated with normal (GK-ND) and high cholesterol
diet. We found that volumetric BMD was lower in
GK-ND rats than the age-matched wild-type controls. In
histomorphometric study of tibial metaphysis, T2DM
evidently suppressed osteoblast function as indicated by
decreases in osteoblast surface, mineral apposition rate,
and bone formation rate in GK-ND rats. Meanwhile, the
osteoclast surface and eroded surface were increased in
GK-ND rats, thus suggesting an activation of bone
resorption. T2DM also impaired bone elongation, presumably
by retaining the chondrogenic precursor cells in
the epiphyseal resting zone. Interestingly, several bone
changes in GK rats (e.g., increased osteoclast surface)
disappeared after high cholesterol treatment as compared
to wild-type rats fed high cholesterol diet. In conclusion,
high cholesterol diet was capable of masking the T2DMinduced
osteopenia and changes in several histomorphometric
parameters that indicated bone microstructural
defect. Cholesterol thus explained, in part, why a decrease
in BMD was not observed in T2DM, and hence delayed
diagnosis of the T2DM-associated bone disease.