Publication: Fetal cranial growth trajectories are associated with growth and neurodevelopment at 2 years of age: INTERBIO-21st Fetal Study
Issued Date
2021-04-01
Resource Type
ISSN
1546170X
10788956
10788956
Other identifier(s)
2-s2.0-85103013721
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Mahidol University
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SCOPUS
Bibliographic Citation
Nature Medicine. Vol.27, No.4 (2021), 647-652
Suggested Citation
José Villar, Robert B. Gunier, Chrystelle O.O. Tshivuila-Matala, Stephen A. Rauch, Francois Nosten, Roseline Ochieng, María C. Restrepo-Méndez, Rose McGready, Fernando C. Barros, Michelle Fernandes, Verena I. Carrara, Cesar G. Victora, Shama Munim, Rachel Craik, Hellen C. Barsosio, Maria Carvalho, James A. Berkley, Leila Cheikh Ismail, Shane A. Norris, Eric O. Ohuma, Alan Stein, Ann Lambert, Adele Winsey, Ricardo Uauy, Brenda Eskenazi, Zulfiqar A. Bhutta, Aris T. Papageorghiou, Stephen H. Kennedy Fetal cranial growth trajectories are associated with growth and neurodevelopment at 2 years of age: INTERBIO-21st Fetal Study. Nature Medicine. Vol.27, No.4 (2021), 647-652. doi:10.1038/s41591-021-01280-2 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/76231
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Title
Fetal cranial growth trajectories are associated with growth and neurodevelopment at 2 years of age: INTERBIO-21st Fetal Study
Author(s)
José Villar
Robert B. Gunier
Chrystelle O.O. Tshivuila-Matala
Stephen A. Rauch
Francois Nosten
Roseline Ochieng
María C. Restrepo-Méndez
Rose McGready
Fernando C. Barros
Michelle Fernandes
Verena I. Carrara
Cesar G. Victora
Shama Munim
Rachel Craik
Hellen C. Barsosio
Maria Carvalho
James A. Berkley
Leila Cheikh Ismail
Shane A. Norris
Eric O. Ohuma
Alan Stein
Ann Lambert
Adele Winsey
Ricardo Uauy
Brenda Eskenazi
Zulfiqar A. Bhutta
Aris T. Papageorghiou
Stephen H. Kennedy
Robert B. Gunier
Chrystelle O.O. Tshivuila-Matala
Stephen A. Rauch
Francois Nosten
Roseline Ochieng
María C. Restrepo-Méndez
Rose McGready
Fernando C. Barros
Michelle Fernandes
Verena I. Carrara
Cesar G. Victora
Shama Munim
Rachel Craik
Hellen C. Barsosio
Maria Carvalho
James A. Berkley
Leila Cheikh Ismail
Shane A. Norris
Eric O. Ohuma
Alan Stein
Ann Lambert
Adele Winsey
Ricardo Uauy
Brenda Eskenazi
Zulfiqar A. Bhutta
Aris T. Papageorghiou
Stephen H. Kennedy
Other Contributor(s)
Faculty of Tropical Medicine, Mahidol University
Center for Environmental Research and Children's Health
University of Sharjah
Wellcome Trust Research Laboratories Nairobi
Aga Khan Hospital Nairobi
The Aga Khan University
London School of Hygiene & Tropical Medicine
Hospital for Sick Children University of Toronto
Green Templeton College
University of Oxford
University of Southampton, Faculty of Medicine
Universidade Catolica de Pelotas
The World Bank Group
University of the Witwatersrand, Johannesburg
Universidade Federal de Pelotas
Wits School of Public Health
Nuffield Department of Medicine
University of Oxford Medical Sciences Division
Center for Environmental Research and Children's Health
University of Sharjah
Wellcome Trust Research Laboratories Nairobi
Aga Khan Hospital Nairobi
The Aga Khan University
London School of Hygiene & Tropical Medicine
Hospital for Sick Children University of Toronto
Green Templeton College
University of Oxford
University of Southampton, Faculty of Medicine
Universidade Catolica de Pelotas
The World Bank Group
University of the Witwatersrand, Johannesburg
Universidade Federal de Pelotas
Wits School of Public Health
Nuffield Department of Medicine
University of Oxford Medical Sciences Division
Abstract
Many observational studies and some randomized trials demonstrate how fetal growth can be influenced by environmental insults (for example, maternal infections)1 and preventive interventions (for example, multiple-micronutrient supplementation)2 that can have a long-lasting effect on health, growth, neurodevelopment and even educational attainment and income in adulthood3. In a cohort of pregnant women (n = 3,598), followed-up between 2012 and 2019 at six sites worldwide4, we studied the associations between ultrasound-derived fetal cranial growth trajectories, measured longitudinally from <14 weeks’ gestation, against international standards5,6, and growth and neurodevelopment up to 2 years of age7,8. We identified five trajectories associated with specific neurodevelopmental, behavioral, visual and growth outcomes, independent of fetal abdominal growth, postnatal morbidity and anthropometric measures at birth and age 2. The trajectories, which changed within a 20–25-week gestational age window, were associated with brain development at 2 years of age according to a mirror (positive/negative) pattern, mostly focused on maturation of cognitive, language and visual skills. Further research should explore the potential for preventive interventions in pregnancy to improve infant neurodevelopmental outcomes before the critical window of opportunity that precedes the divergence of growth at 20–25 weeks’ gestation.