Publication: Elevated plasma concentrations of interferon (IFN)-γ and the IFN-γ- inducing cytokines interleukin (IL)-18, IL-12, and IL-15 in severe melioidosis
Issued Date
1999-12-17
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ISSN
00221899
DOI
Other identifier(s)
2-s2.0-0032708938
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Mahidol University
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SCOPUS
Bibliographic Citation
Journal of Infectious Diseases. Vol.180, No.6 (1999), 1878-1885
Suggested Citation
Fanny N. Lauw, Andrew J.H. Simpson, Jan M. Prins, Michael D. Smith, Masashi Kurimoto, Sander J.H. Van Deventer, Peter Speelman, Wipada Chaowagul, Nicholas J. White, Tom Van Der Poll Elevated plasma concentrations of interferon (IFN)-γ and the IFN-γ- inducing cytokines interleukin (IL)-18, IL-12, and IL-15 in severe melioidosis. Journal of Infectious Diseases. Vol.180, No.6 (1999), 1878-1885. doi:10.1086/315155 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/25491
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Title
Elevated plasma concentrations of interferon (IFN)-γ and the IFN-γ- inducing cytokines interleukin (IL)-18, IL-12, and IL-15 in severe melioidosis
Abstract
Interferon (IFN)-γ plays an important role in the pathogenesis of sepsis. Production of IFN-γ is stimulated by synergistic effects of interleukin (IL)-18, IL-12, and IL-15. To investigate the regulation of IFN- γ production during severe gram-negative infection, the plasma concentrations of IFN-γ, IL-18, IL-12, and IL-15 were measured in 83 patients with suspected melioidosis. The diagnosis was confirmed in 62 patients, 31 of whom had blood cultures positive for Burkholderia pseudomallei, of whom 12 died. Compared with healthy controls, patients had elevated levels of [FN-γ, IL-18, IL-12p40, and IL-15 on admission, with significantly higher levels in blood culture-positive patients, and these levels remained elevated during the 72-h study period. In whole blood stimulated with heat-killed B. pseudomallei, anti-IL-12 had a stronger inhibitory effect than anti-IL-18 and anti-IL-15 on IFN-γ production. This effect of anti-IL-12 was further enhanced by anti-IL-18. These data suggest that during gram-negative sepsis, IFN-γ production is controlled at least in part by endogenous IL-18, IL-12, and IL-15.